Predicting success of glaucoma surgery using trabeculopuncture

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to develop a non-invasive test called trabeculopuncture to assess the function of the distal outflow tract in patients with open angle glaucoma. By measuring changes in ocular pressure and outflow before surgery, the researchers hope to predict the success of ab interno trabeculectomy. This approach could help tailor surgical interventions to individual patient needs, potentially improving outcomes. The study will involve patients who have uncontrolled intraocular pressure despite medical therapy and show signs of glaucoma progression.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* individuals ≥ 18 years of age
* clinical diagnosis of: primary open angle glaucoma, pigmentary glaucoma, or pseudoexfoliation glaucoma
* uncontrolled intraocular pressure (IOP) with maximally tolerated medical therapy
* progressive thinning of retinal nerve fiber layer assessed by Spectral domain optical coherence tomography (p \< 0.05)
* progression of visual field defects
* visually significant cataract and indication to reduce IOP or glaucoma medication burden

Exclusion Criteria:

* clinical diagnosis of neovascular glaucoma, angle-closure glaucoma, uveitic glaucoma, neovascular glaucoma
* prior glaucoma surgery
* preexisting conditions affecting the episcleral venous pressure including Grave's ophthalmopathy, Sturge-Weber syndrome, Arteriovenous fistulas (carotid-cavernous fistula)

Where it's running

• Uniklinikum Würzburg
  Würzburg, Bavaria, Germany Recruiting

Study contacts

• Principal investigator: Daniel Kampik, MD, PhD — Department of Ophthalmology University Hospital Würzburg
• Study coordinator: Raoul Verma-Fuehring, MD
• Email: vermafuehr_R@ukw.de
• Phone: +49 93120120662

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.