Evaluating the effectiveness of surgical systems for treating open-angle glaucoma

Real-World Efficacy of Hydrus Microstent With OMNI Surgical System in Combination With Phacoemulsification: a Retrospective Analysis

Observational Barnet Dulaney Perkins Eye Centers · NCT06953349

This study looks at how well a combination of surgical treatments can lower eye pressure in people with open-angle glaucoma over three years.

Quick facts

Study typeObservational
Enrollment300 (estimated)
Ages18 Years and up
SexAll
SponsorBarnet Dulaney Perkins Eye Centers Research network
Locations1 site (Mesa, Arizona)
Trial IDNCT06953349 on ClinicalTrials.gov

What this trial studies

This observational study analyzes the real-world efficacy of the Hydrus Microstent combined with the OMNI Surgical System and Phacoemulsification in patients with open-angle glaucoma. It focuses on patients who have undergone these procedures and have at least three years of follow-up data. The study aims to assess how well this combination treatment lowers intraocular pressure (IOP) in a diverse patient population. By utilizing retrospective data, the study seeks to provide insights into the long-term outcomes of these surgical interventions.

Who should consider this trial

Good fit: Ideal candidates include patients with a history of cataract surgery and those who have been on multiple medications for glaucoma prior to surgery.

Not a fit: Patients with angle closure glaucoma, secondary glaucoma, or those who have had prior incisional surgery may not benefit from this study.

Why it matters

Potential benefit: If successful, this study could lead to improved treatment options for patients with open-angle glaucoma, potentially enhancing their quality of life.

How similar studies have performed: Other studies have shown promising results with similar surgical approaches, indicating potential for success in this analysis.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Subjects with h/o CEIOL/OMNI/Hydrus (chosen based on subjects on more than 1 medication pre-operatively) with at least 3 years of follow up data
* have Glaucoma

Exclusion Criteria:

* Patients with angle closure glaucoma or secondary forms of glaucoma due to neovascularization of the angle, uveitic glaucoma, congenital glaucoma, or glaucoma due to congenital anomalies.
* Patients with refractory CME or CME persisting 3 months or more post-operatively
* Patients with incomplete IOP, medication logs or VF data within post-operative period
* Prior incisional surgery or MIGS

Where this trial is running

Mesa, Arizona

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions Open-Angle GlaucomaHydrus MicrostentOMNI Surgical SystemPhacoemulsification
Last reviewed 2026-06-09 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.