Condition

Obstructive Sleep Apnea (OSA) clinical trials and research

• 41Clinical trials
• 24Countries

Newest Obstructive Sleep Apnea (OSA) clinical trials

All recruiting trials (41)

• F&P Mask usability in home PAP/NIV care for adults with chronic breathing conditions

  This study tests how well the F&P Licorice Mask works at home for adults who already use PAP or NIV therapy.

  Recruiting Fisher and Paykel Healthcare · St Louis, Missouri · NCT07826429

• Sleep apnea biomarkers and CPAP use after diagnosis

  This study tests whether biomarkers from a diagnostic sleep study can predict how well adults with newly diagnosed obstructive sleep apnea will stick to CPAP therapy after about 3 months.

  Recruiting Clinique du Millenaire · Montpellier · NCT07792746

• Using the PLATO Questionnaire in Oral Appliance Therapy for Obstructive Sleep Apnea

  This real-world study tests whether the PLATO questionnaire can be feasibly used in dental sleep clinics for patients receiving oral appliance therapy for obstructive sleep apnea.

  Recruiting Nevada Dental Sleep · Henderson, Nevada · NCT07789834

• Managing COMISA: adding daridorexant to CPAP may help sleep and CPAP use

  This study tests whether adding daridorexant to CPAP helps people with COMISA better stick with CPAP and feel better.

  Recruiting University Hospital, Grenoble · Grenoble and 4 other locations · NCT07743931

• OSA Screening in Diverse Populations

  This study tests how common obstructive sleep apnea is across community members and people with certain diseases in China, using screening questionnaires and polysomnography or portable sleep monitors.

  Recruiting Guangzhou Institute of Respiratory Disease · Guangzhou, Guangdong and 1 other locations · NCT07736872

• Wall Squat Exercise to Help Lower Blood Pressure in Adults with Hypertension and Sleep Apnea

  This study tests whether doing an isometric wall squat can lower blood pressure in adults who have high blood pressure and sleep apnea treated with CPAP.

  Recruiting Aveiro University · Braga · NCT07730879

• Biomarkers in Obstructive Sleep Apnea: Could Blood Tests Help Screen and Track OSA?

  This study tests whether blood biomarkers can help screen for, diagnose, and monitor obstructive sleep apnea in adults, including an analysis of treatment response with PAP therapy.

  Recruiting Medical University of Bialystok · Bialystok, Podlaskie Voivodeship · NCT07723144

• Scarlet WhisperPT: a comfortable in-ear cue device to reduce sleep on the back for positional sleep apnea

  This study tests WhisperPT, an in-ear device that gives gentle audio cues at night to help people with positional obstructive sleep apnea sleep more in non-supine positions and see if it lowers breathing disruption.

  Recruiting SleepDev, Inc · Burlingame, California · NCT07714330

• Comparative test of PAP therapy, a dental device, and atomoxetine-oxybutynin for adults with obstructive sleep apnea

  This study tests three options for obstructive sleep apnea to see which works best and is easiest for patients to use.

  Recruiting at 3 sites Phase 4 University of Arizona · Tucson, Arizona and 3 other locations · NCT07679282

• Dronabinol and Acetazolamide Medication for Sleep Apnea dose test in adults with obstructive sleep apnea

  This study tests whether different doses of IHL-42X, a combination of dronabinol and acetazolamide, can improve sleep apnea symptoms in adults who can’t or won’t use CPAP.

  Recruiting at 12 sites Phase 2 Incannex Healthcare Ltd · Chula Vista, California and 12 other locations · NCT07635563

• Fluid removal and sleep apnea changes in heart failure patients

  This study tests whether removing excess fluid in adults with heart failure improves their sleep apnea while in the hospital.

  Recruiting Shaare Zedek Medical Center · Jerusalem · NCT07601724

• Early screening for sleep-disordered breathing in kids at the dentist

  This study tests whether a simple kid-friendly questionnaire can flag risk for sleep-disordered breathing in children aged 8–13 when checked during a dental visit.

  Recruiting University of North Carolina, Chapel Hill · Chapel Hill, North Carolina · NCT07581938

• Changing electrical stimulation frequency to affect tongue muscle activity

  This test tries different electrical stimulation frequencies on the tongue and submental muscles to see if they change tongue strength and muscle size in adults at high risk for sleep apnea.

  Recruiting Seoul National University Bundang Hospital · Gyeonggi-do, Seongnam-si · NCT07466888

• Remote CPAP monitoring for severe obstructive sleep apnea in primary care

  This will test whether remote monitoring of CPAP devices helps adults with severe obstructive sleep apnea treated in primary care use their therapy more and improve symptoms.

  Recruiting Federal University of São Paulo · São Paulo, São Paulo · NCT07464262

• Improving Sleep in African American Couples: A CPAP Adherence Study

  This study tests whether a couple-focused program including remote monitoring, virtual therapy, and peer support can help African American adults with moderate to severe sleep apnea use CPAP more consistently and sleep better.

  Recruiting MetroHealth Medical Center · Cleveland, Ohio and 1 other locations · NCT07447284

• Tongue ultrasound for children and teens with obesity

  For children and teens with obesity enrolled in a 30-week inpatient weight-loss program, this project uses ultrasound to see if tongue size, fat content, and stiffness relate to body measurements and sleep apnea and change after the program.

  Recruiting Haute Ecole Bruxelles-Brabant · Brussels and 1 other locations · NCT07370350

• Portable sleep monitors for children with autism

  This study will test whether a small portable sleep monitor (Nox T3s) can find obstructive sleep apnea in children aged 6–18 with autism by comparing it to an in-hospital polysomnogram.

  Recruiting University of British Columbia · Vancouver, British Columbia · NCT07367022

• Adenotonsillectomy and spinal curve changes in children with sleep-disordered breathing

  This trial will test whether removing the adenoids and tonsils can reduce or prevent worsening of spinal curves in children aged 6–15 who have mild sleep-disordered breathing and scoliosis or are at risk.

  Recruiting Second Affiliated Hospital of Wenzhou Medical University · Wenzhou, Zhejiang · NCT07332780

• High-flow nasal oxygen to prevent low oxygen during sedated endoscopy in people with high-risk sleep apnea

  This will test whether using high‑flow nasal oxygen instead of a regular nasal cannula prevents low oxygen levels during propofol‑sedated gastroscopy or colonoscopy in adults with high‑risk obstructive sleep apnea (STOP‑Bang ≥5).

  Recruiting at 3 sites Zhejiang University · Hangzhou, Zhejiang and 2 other locations · NCT07307560

• Low-tech breathing and drinking exercises for obstructive sleep apnea.

  This project will try two simple breathing-and-drinking exercise programs to see if they help adults (18–65) with obstructive sleep apnea sleep better and whether results differ for people with prior traumatic brain injury.

  Recruiting Phase 1/2 Uniformed Services University of the Health Sciences · Bethesda, Maryland · NCT07301710

• App-guided orofacial muscle training for mild to moderate obstructive sleep apnea.

  This trial will test a three-month app-delivered facial-recognition guided orofacial exercise program to see if it reduces sleep apnea severity and symptoms in adults with mild to moderate OSA who cannot tolerate or decline CPAP or oral appliances.

  Recruiting Hong Kong Metropolitan University · Hong Kong, Hong Kong · NCT07292922

• Endotype-directed treatment for obstructive sleep apnea in people with Down syndrome

  This project will test whether a precision approach—using atomoxetine plus oxybutynin for some people and oxygen for others based on breathing patterns—works better than giving atomoxetine-plus-oxybutynin to everyone with Down syndrome and obstructive sleep apnea.

  Recruiting at 5 sites Phase 4 University of Arizona · Tucson, Arizona and 4 other locations · NCT07280468

• Myofunctional therapy for children with obstructive sleep apnea

  This study tests whether myofunctional therapy helps children aged 6–12 who have obstructive sleep apnea see improvements in sleep and breathing.

  Recruiting Chinese University of Hong Kong · Shatin · NCT07249944

• Orofacial muscle training for children with obstructive sleep apnea

  This trial will test whether 12 weeks of orofacial muscle exercises help children aged 6–12 with obstructive sleep apnea (AHI > 1) sleep better and feel better during the day.

  Recruiting University Hospital, Ghent · Ghent · NCT07129967

• Orofacial muscle therapy for children with Down syndrome or Prader–Willi syndrome and obstructive sleep apnea

  We will test whether 20 weeks of orofacial myofunctional therapy can reduce obstructive sleep apnea and improve sleep-related quality of life in children with Down syndrome or Prader–Willi syndrome.

  Recruiting University Hospital, Ghent · Ghent · NCT07122505

• Telehealth care with a human sleep navigator for obstructive sleep apnea in the military health system

  This study will test whether telehealth OSA care that includes a human sleep navigator works as well and costs less than private-sector care for TRICARE beneficiaries newly diagnosed with obstructive sleep apnea.

  Recruiting Uniformed Services University of the Health Sciences · Bethesda, Maryland and 1 other locations · NCT07121452

• Inspire UAS for very severe OSA and higher-BMI adults

  This study tests whether the implanted Inspire upper airway stimulation (UAS) system is safe and works long-term for adults with very severe obstructive sleep apnea or higher BMI who cannot use CPAP.

  Recruiting at 5 sites Inspire Medical Systems, Inc. · Colorado Springs, Colorado and 4 other locations · NCT07113288

• Preventing bite changes from mandibular advancement sleep devices with a morning aligner or jaw exercises.

  This test compares a removable morning interocclusal aligner to daily jaw exercises to see if they prevent bite changes in adults using mandibular advancement devices for sleep apnea or snoring.

  Recruiting University of Kentucky · Lexington, Kentucky · NCT07103941

• How different CPAP mask exhaust flows affect CO2 rebreathing

  This test will see if different CPAP mask exhaust flows change how much exhaled carbon dioxide people with moderate to severe OSA might rebreathe during sleep.

  Recruiting Brigham and Women's Hospital · Boston, Massachusetts · NCT07062770

• Hypoglossal nerve stimulation for adults with obstructive sleep apnea

  This study will test an implanted hypoglossal nerve stimulator to see if it reduces sleep apnea events and improves sleep for adults with moderate to severe OSA who cannot tolerate CPAP.

  Recruiting at 6 sites XII Medical · Canberra, Australian Capital Territory and 5 other locations · NCT07049744

• Improving CPAP use in adults with severe sleep apnea through motivation and psychological factors

  This study is testing if a motivational phone call can help adults with severe sleep apnea stick to their CPAP therapy better than those who don’t get the call.

  Recruiting University of Split, School of Medicine · Split, Dalmatia · NCT06994247

• CPAP versus mandibular advancement mouthpiece for sleep apnea in people with mild cognitive impairment

  This project will try to see if a mandibular advancement device (a dental mouthpiece) works as well as nightly CPAP to improve thinking and memory in people over 45 with moderate-to-severe obstructive sleep apnea and mild cognitive impairment.

  Recruiting National University Hospital, Singapore · Kent Ridge, Please Select · NCT06983769

• EURO-STIM: Long-term tracking of Inspire therapy for obstructive sleep apnea

  This registry will track people with obstructive sleep apnea who have an Inspire implant to see how they use the device over time and how well they stick with therapy.

  Recruiting at 3 sites Inspire Medical Systems, Inc. · Klagenfurt and 20 other locations · NCT06971796

• New method for diagnosing obstructive sleep apnea using muscle activity measurements

  This study is trying out a new, painless way to diagnose obstructive sleep apnea by measuring muscle activity in the mouth and throat to see if it can provide accurate results.

  Recruiting University of California, San Diego · San Diego, California · NCT06944782

• New ways to spot obstructive sleep apnea using facial scans, videos, and heart rate patterns

  This study tests whether facial scans, short videos of facial movements, and heart rate variability can help diagnose obstructive sleep apnea in adults.

  Recruiting ResMed · Sydney, New South Wales · NCT06930404

• Evaluating a Sleep Tracking Mat for Diagnosing Sleep Apnea

  This study is testing a new sleep tracking mat to see if it can accurately diagnose sleep apnea in a simpler and more convenient way than traditional methods.

  Recruiting Shanghai 6th People's Hospital · Shanghai, Shanghai Municipality · NCT06875479

• Driving-simulator sleepiness test compared with the standard wakefulness test for people with OSA after pausing CPAP

  This research will test whether a naturalistic driving-simulator sleepiness test can detect dangerous sleepiness behind the wheel in adults with obstructive sleep apnea after temporarily stopping CPAP treatment.

  Recruiting University of Zurich · Zurich, ZRH · NCT06872593

• New classification for sleep apnea based on daytime sleepiness and heart risk

  We will test whether combining daytime sleepiness and cardiovascular risk scores can better predict long-term outcomes for adults newly diagnosed with obstructive sleep apnea.

  Recruiting at 12 sites Wissenschaftliches Institut Bethanien e.V · Antwerp, Antwerp and 17 other locations · NCT06861686

• Home smartphone videos to detect obstructive sleep apnea in children

  This project will test whether short smartphone videos recorded by parents can help spot moderate-to-severe obstructive sleep apnea in children ages 2–18 who are being referred for a sleep study.

  Recruiting at 3 sites Children's Hospital of Eastern Ontario · Edmonton, Alberta and 3 other locations · NCT06801366

• Optic nerve blood flow and injury in people with obstructive sleep apnea

  This study will test if CPAP treatment and how severe someone's sleep apnea is affect optic nerve blood flow and the risk of ischemic optic neuropathy in adults with obstructive sleep apnea.

  Recruiting Nanjing Medical University · Nanjing, Jiangsu · NCT06748703

• Motivational program to improve sleep quality in patients with sleep apnea

  This study is testing a new motivational program to see if it can help adults with sleep apnea sleep better and stick to their CPAP therapy.

  Recruiting at 2 sites Fondazione Don Carlo Gnocchi ETS · Milan, Milan and 1 other locations · NCT06668597

Related topics

Quick answers

How many Obstructive Sleep Apnea (OSA) clinical trials are recruiting right now?

41, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 24 countries. The most sites are in United States (14 trials), China (5 trials), Belgium (5 trials), France (4 trials), Switzerland (3 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 4: 2, Phase 1/2: 1, Phase 2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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