Wall Squat Exercise to Help Lower Blood Pressure in Adults with Hypertension and Sleep Apnea

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Participants with hypertension and obstructive sleep apnea on CPAP will complete two sessions in random order: one with a single isometric wall squat exercise and one with a non-exercise control. The design compares blood pressure changes within the same person to minimize variability. After a familiarization visit, eligible participants perform the two sessions under guided conditions and CPAP use is monitored. Outcomes focus on acute blood pressure response to the wall squat compared with no exercise.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* 18-80 years old.
* Diagnosis of hypertension and OSA confirmed by polysomnography or respiratory sleep study.
* Apnea-Hypopnea Index (AHI) of at least 15 events per hour.
* Treatment with CPAP for at least 3 months.

Exclusion Criteria:

* Mean CPAP adherence \<4 hours/night over the last month, documented by device download.
* Heart failure.
* Peripheral artery disease.
* Atrial fibrillation.
* Chronic obstructive pulmonary disease.
* Chronic kidney disease.
* History of acute coronary syndrome, stroke, or transient ischemic attack in the previous 12 months.
* Relevant changes in antihypertensive or other cardiovascular pharmacotherapy in the previous 3 months.
* Relevant changes in CPAP prescription in the previous 3 months.
* Any contraindication to exercise according to contemporary ESC/ACSM recommendations (e.g. unstable angina).
* Pregnancy or breastfeeding.
* Neurological and/or orthopaedic conditions that could interfere with exercise (e.g. severe knee osteoarthritis, recent lower-limb surgery).
* Inability to read, understand, or provide informed consent.

Where it's running

• Nippon Sanso Homecare
  Braga, Portugal Recruiting

Study contacts

• Principal investigator: Fernando Ribeiro, PhD — University of Aveiro, Aveiro, Portugual
• Study coordinator: Fernando Ribeiro, PhD
• Email: fernando.ribeiro@ua.pt
• Phone: +351234372455

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.