Optic nerve blood flow and injury in people with obstructive sleep apnea
Official title: Optic Nerve Injury and the Effect of CPAP Treatment in Obstructive Sleep Apnea Patients
Run by Nanjing Medical University · NCT06748703 · Data updated 2026-11-12
This study will test if CPAP treatment and how severe someone's sleep apnea is affect optic nerve blood flow and the risk of ischemic optic neuropathy in adults with obstructive sleep apnea.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 80 Years |
| Sex | All |
| Enrollment | 80 (estimated) |
| Sponsor | Nanjing Medical University Academic / other |
| Locations | 1 site (Nanjing, Jiangsu) |
| Status | Recruiting |
| Started | January 1, 2025 |
| Main results expected | December 31, 2025 |
| Study ends | January 31, 2026 |
| Registry record updated | June 27, 2025 |
| Trial ID | NCT06748703 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults 18–80 with a new diagnosis of OSA (AHI ≥ 5/h), who have not had prior CPAP or OSA surgery and can provide informed consent, are ideal candidates.
✕Probably not a fit
Patients with severe cerebrovascular disease, advanced vascular complications of diabetes, severe COPD, pulmonary hypertension, heart failure, pregnancy, or other major comorbidities are excluded and unlikely to benefit from this protocol.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
The trial will enroll 80 adults (ages 18–80) with newly diagnosed obstructive sleep apnea who have not previously received CPAP or OSA surgery. Participants will undergo baseline polysomnography to determine apnea-hypopnea index (AHI) and be grouped into mild, moderate, or severe OSA. Ophthalmologic testing will include optic nerve and macular blood-flow OCT, visual acuity, refraction, intraocular pressure, visual fields, and axial measurements. Eligible participants will receive CPAP treatment and be followed to compare ocular blood-flow measures and signs of ischemic optic neuropathy across severity groups and with treatment.
Why it matters
Potential benefit: If successful, the trial could show that treating OSA with CPAP preserves or improves optic nerve blood flow and lowers the risk of ischemic optic neuropathy, potentially preventing vision loss.
How similar studies have gone: Smaller observational studies have reported associations between OSA and optic nerve ischemia and some ocular blood-flow changes with CPAP, but robust interventional evidence is still limited.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Patients aged between 18 and 80 years. 2. Diagnosed with Obstructive Sleep Apnea Hypopnea Syndrome (OSAHS)(apnea-hypopnea index≥5/h). 3. First-time diagnosis, with no previous surgical interventions or CPAP treatment for OSA. 4. Ability and willingness to provide informed consent for participation in the study. Exclusion Criteria: 1. History of severe stroke or cerebral hemorrhage, or presence of neurological or psychiatric conditions that could affect study results. 2. Presence of active malignancies or other severe underlying diseases, such as severe liver or kidney dysfunction. Diagnosed with diabetes or other significant vascular diseases. 3. Presence of severe chronic obstructive pulmonary disease (COPD), severe asthma, severe pulmonary hypertension, or heart failure caused by any condition. 4. Pregnancy or having other conditions that make participation in this study unsuitable. 5. Extremely debilitated patients or those with severe underlying conditions.
Where it's running
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The First Affiliated Hospital of Nanjing Medical University
Nanjing, Jiangsu, China Recruiting
Study contacts
- Study coordinator: Ning Ding,MD,PhD
- Email: dr.ningding@live.cn
- Phone: 86-25-68136723
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.