Comparative test of PAP therapy, a dental device, and atomoxetine-oxybutynin for adults with obstructive sleep apnea
Official title: Comparative Effectiveness of Positive Airway Pressure Therapy, Dental Device, and Atomoxetine-Oxybutynin for Sleep Apnea: the ADAPT-OSA Study
Run by University of Arizona · NCT07679282 · Data updated 2026-11-12
This study tests three options for obstructive sleep apnea to see which works best and is easiest for patients to use.
Quick facts
| Phase | Phase 4 |
|---|---|
| Study type | Interventional |
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 2400 (estimated) |
| Sponsor | University of Arizona Academic / other |
| Locations | 4 sites (Tucson, Arizona and 3 other locations) |
| Status | Recruiting |
| Started | September 4, 2026 |
| Main results expected | March 1, 2030 |
| Study ends | May 1, 2032 |
| Registry record updated | October 19, 2026 |
| Trial ID | NCT07679282 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults diagnosed with OSA (AHI ≥ 5) within the past 6 months who are willing to try any of the three treatments.
✕Probably not a fit
Participants who do not benefit from any of the three treatments or cannot adhere to them may see little to no improvement.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
Adults with obstructive sleep apnea are randomly assigned to one of three treatments for a year: standard PAP therapy, a dental device, or a combination of atomoxetine and oxybutynin. The study monitors adherence, symptoms, and side effects through in-person visits and phone check-ins. It uses a phase 4, interventional design to compare real-world effectiveness across these options. Outcomes will inform which treatment is most tolerable and effective for sustained use.
Why it matters
Potential benefit: If successful, the best-performing treatment could improve sleep, symptoms, and daily functioning for people with OSA.
How similar studies have gone: Prior studies have explored PAP and dental devices, with mixed results; this trial adds a direct comparison including a pharmacologic option.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Obstructive sleep apnea (AHI \>/= 5 per hour), diagnosed in the past 6 months * Two or more of the following symptoms: snoring, fragmented sleep, witnessed apneas, or daytime sleepiness * Willingness/ability to use any of the 3 treatments for OSA (PAP, dental device, or atomoxetine-oxybutynin) * Health insurance of any type Exclusion Criteria: * Prior treatment for OSA in past year * Central sleep apnea or narcolepsy * Contraindication for dental device (temporomandibular joint problems, severe periodontal disease, insufficient dentition) * Heart failure with reduced ejection fraction of \</= 45% * Active coronary artery disease (angina or infarction within 3 months of enrollment) * Current untreated depression * Untreated narrow angle glaucoma * Untreated hypothyroidism * Clinically significant gastric retention * Clinically significant urinary retention * History of liver disease * Seizure disorder * Pregnant or nursing, or plans to become pregnant within the year * Concomitant medication use that is incompatible with atomoxetine or oxybutynin * Participation in another clinical study with an investigational product
Where it's running
-
Banner University Medical Center Tucson
Tucson, Arizona, United States Recruiting -
Stanford Medical Center
Redwood City, California, United States Recruiting -
University of Maryland Baltimore
Baltimore, Maryland, United States Recruiting -
University of Miami Miller School of Medicine
Miami, Florida, United States Not yet recruiting
Study contacts
- Principal investigator: Sairam Parthasarathy, MD — University of Arizona
- Study coordinator: Heidi Erickson, BSN, RN
- Email: herickso@arizona.edu
- Phone: 1-520-626-5287
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.