Using Magnetic Resonance Fingerprinting to Evaluate Breast Cancer Treatment Response
Official title: Development of Magnetic Resonance Fingerprinting (MRF) to Assess Response to Neoadjuvant Chemotherapy in Breast Cancer
Funded at Case Western Reserve University · NIH-10894084 · Data updated 2026-11-12
This study is testing a new imaging method to help doctors see how well breast cancer patients are responding to their chemotherapy before surgery, so they can make better treatment decisions and improve results.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Case Western Reserve University NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project start | September 1, 2023 |
| Project end | August 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $536,972 |
| NIH project number | 5R01CA282516-02 |
| Project ID | NIH-10894084 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are women diagnosed with breast cancer who are scheduled to undergo neoadjuvant chemotherapy.
✕Less likely to help
Patients who are not undergoing neoadjuvant chemotherapy or those with non-breast cancer diagnoses may not benefit from this research.
What this research studies
This research focuses on developing a new imaging technique called Magnetic Resonance Fingerprinting (MRF) to assess how well breast cancer patients respond to neoadjuvant chemotherapy before surgery. The goal is to identify patients who are not responding to treatment early on, allowing for adjustments to their therapy to improve outcomes. By providing a more objective and quantitative measure of tumor changes, this approach aims to enhance the accuracy of treatment planning and reduce unnecessary side effects. The study will involve advanced imaging techniques that can detect biological changes in tumors more quickly than traditional methods.
Why it matters
Potential benefit: If successful, this research could lead to more personalized and effective treatment plans for breast cancer patients, improving their chances of survival.
How similar studies have gone: Previous research has shown promise in using advanced imaging techniques for monitoring treatment response, suggesting that this approach could be effective.
Where this research is happening
-
Case Western Reserve University
Cleveland, United States Active
Researchers
- Principal investigator: Chen, Yong — Case Western Reserve University
- Study coordinator: Chen, Yong
Related research
Other NIH-funded projects on the same topics.
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Magnetic resonance fingerprinting to gauge chemotherapy response in breast cancer
A patient-facing look at using a special MRI method (MRF) to see early whether breast cancer is responding to preliminary chemotherapy.
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3D wearable NIR imaging to predict breast cancer response during treatment
A noninvasive, portable 3D wearable optical test (NIRS tomography) will be used to spot early signs of how breast cancer is responding to chemotherapy, helping guide treatment for patients.
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MRI fingerprinting to spot early breast tumor response to chemotherapy given before surgery
This project uses a new MRI method to find early changes in breast tumors during chemotherapy given before surgery so doctors can change treatment sooner if needed.
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Improving how we track breast cancer chemotherapy with 3D imaging
This project aims to develop a new 3D ultrasound method to see how well chemotherapy is working for breast cancer patients before surgery.
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New Wearable Imaging to See How Breast Cancer Responds to Chemotherapy
This project is developing a new wearable imaging device to help doctors see very early if breast cancer treatment is working for patients receiving chemotherapy before surgery.
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Using 3D wearable technology to predict breast cancer treatment outcomes
This study is testing a new, easy-to-use imaging method that helps doctors see how well chemotherapy is working for breast cancer patients, so they can better understand how much cancer is left after treatment and improve chances for a healthier future.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.