How pre-surgery chemotherapy affects breast cancer spread
Prometastatic Effects of Neoadjuvant Chemotherapy in Breast Cancer
['FUNDING_OTHER'] · ALBERT EINSTEIN COLLEGE OF MEDICINE · NIH-10915646
This study is looking at how chemotherapy for breast cancer might sometimes help cancer cells spread to other parts of the body, and it aims to understand the role of certain immune cells in this process, which could lead to better treatment options for patients like you.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | ALBERT EINSTEIN COLLEGE OF MEDICINE (nih funded) |
| Locations | 1 site (BRONX, UNITED STATES) |
| Trial ID | NIH-10915646 on ClinicalTrials.gov |
What this research studies
This research investigates the effects of neoadjuvant chemotherapy on breast cancer, particularly how it may inadvertently promote the spread of cancer cells to other parts of the body. The study focuses on understanding the changes in the tumor microenvironment caused by chemotherapy, specifically the role of certain immune cells called macrophages. By examining these changes in both mouse models and patient-derived samples, the researchers aim to identify biomarkers and pathways that could help predict and potentially prevent chemotherapy-induced metastasis. This could lead to improved treatment strategies for patients undergoing chemotherapy for breast cancer.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with early-stage breast cancer who are scheduled to receive neoadjuvant chemotherapy.
Not a fit: Patients with metastatic breast cancer or those not receiving chemotherapy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies that prevent the spread of breast cancer during chemotherapy, improving patient outcomes.
How similar studies have performed: Other research has indicated that understanding the tumor microenvironment can lead to significant advancements in cancer treatment, suggesting that this approach has potential for success.
Where this research is happening
BRONX, UNITED STATES
- ALBERT EINSTEIN COLLEGE OF MEDICINE — BRONX, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KARAGIANNIS, GEORGE S — ALBERT EINSTEIN COLLEGE OF MEDICINE
- Study coordinator: KARAGIANNIS, GEORGE S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.