Improving how we track breast cancer chemotherapy with 3D imaging
Official title: Monitoring neoadjuvant chemotherapy of breast cancer using 3D subharmonic aided pressure estimation
Funded at Thomas Jefferson University · NIH-11160431 · Data updated 2026-11-12
This project aims to develop a new 3D ultrasound method to see how well chemotherapy is working for breast cancer patients before surgery.
Quick facts
| Grant type | R37 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Thomas Jefferson University NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | July 1, 2019 |
| Project end | May 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $450,130 |
| NIH project number | 5R37CA234428-07 |
| Project ID | NIH-11160431 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients undergoing neoadjuvant chemotherapy for breast cancer who might benefit from more precise monitoring of their treatment response would be ideal candidates.
✕Less likely to help
Patients who are not receiving neoadjuvant chemotherapy for breast cancer or those with other cancer types would likely not receive direct benefit from this specific imaging technique.
What this research studies
For patients with breast cancer, chemotherapy is often given before surgery to shrink tumors. This project is developing a new way to monitor these treatments using a special 3D ultrasound technique. This advanced imaging method measures changes in tumor stiffness, which can tell doctors if the chemotherapy is effectively shrinking the cancer. By getting a clearer picture of treatment response earlier, doctors can make more informed decisions about a patient's care.
Why it matters
Potential benefit: If successful, this new imaging technique could help doctors better understand how breast cancer chemotherapy is working, potentially leading to more personalized and effective treatment plans.
How similar studies have gone: While ultrasound is a common imaging tool, this specific 3D subharmonic aided pressure estimation technique for monitoring neoadjuvant chemotherapy in breast cancer appears to be a novel application.
Where this research is happening
-
Thomas Jefferson University
Philadelphia, United States Active
Researchers
- Principal investigator: Nam, Kibo — Thomas Jefferson University
- Study coordinator: Nam, Kibo
Related research
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-
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MRI fingerprinting to spot early breast tumor response to chemotherapy given before surgery
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New Wearable Imaging to See How Breast Cancer Responds to Chemotherapy
This project is developing a new wearable imaging device to help doctors see very early if breast cancer treatment is working for patients receiving chemotherapy before surgery.
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Using 3D wearable technology to predict breast cancer treatment outcomes
This study is testing a new, easy-to-use imaging method that helps doctors see how well chemotherapy is working for breast cancer patients, so they can better understand how much cancer is left after treatment and improve chances for a healthier future.
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How pre-surgery chemotherapy affects breast cancer spread
This study is looking at how chemotherapy for breast cancer might sometimes help cancer cells spread to other parts of the body, and it aims to understand the role of certain immune cells in this process, which could lead to better treatment options for patients like you.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.