Condition

Advanced Hepatocellular Carcinoma clinical trials and research

• 31Clinical trials
• 2NIH research projects
• 9Countries

Newest Advanced Hepatocellular Carcinoma clinical trials

All recruiting trials (31)

• Morning versus afternoon immunotherapy for advanced or metastatic solid tumors

  This trial tests whether giving standard immune checkpoint inhibitor therapy in the morning versus the afternoon changes outcomes for adults with advanced or metastatic solid tumors.

  Recruiting Phase 4 OHSU Knight Cancer Institute · Portland, Oregon · NCT07405086

• PF-08634404 alone or with ipilimumab for adults with advanced hepatocellular carcinoma not removable by surgery

  This tests PF-08634404 by itself and together with ipilimumab in adults whose hepatocellular carcinoma is advanced and cannot be removed surgically.

  Recruiting at 60 sites Phase 1/2 Pfizer · Irvine, California and 59 other locations · NCT07227012

• Celecoxib with durvalumab and tremelimumab for advanced liver cancer

  This phase II trial tests whether adding the oral drug celecoxib to the immunotherapy drugs durvalumab and tremelimumab helps people with advanced or metastatic liver cancer.

  Recruiting at 3 sites Phase 2 Emory University · Atlanta, Georgia and 3 other locations · NCT07174570

• Immunotherapy with or without targeted high-dose liver radiation (SBRT) for advanced liver cancer

  This trial will see if adding targeted high-dose liver radiation (SBRT) to standard immunotherapy helps people with advanced liver cancer that has invaded blood vessels.

  Recruiting at 139 sites Phase 3 NRG Oncology · Berkeley, California and 138 other locations · NCT07166406

• Zanzalintinib for advanced liver cancer after prior treatment

  This phase Ib/II study tests if zanzalintinib is safe and tolerable and if it can help people with advanced liver cancer after other therapies.

  Recruiting Phase 1/2 Northwestern University · Chicago, Illinois · NCT07042919

• BL-B01D1 plus lenvatinib for advanced hepatocellular carcinoma

  This trial tests whether adding BL-B01D1 to lenvatinib helps people with advanced hepatocellular carcinoma shrink tumors or slow disease progression.

  Recruiting Phase 2 Sichuan Baili Pharmaceutical Co., Ltd. · Shanghai, Shanghai Municipality · NCT06986785

• Sapanisertib plus cabozantinib for metastatic liver cancer with beta-catenin changes

  This trial tests whether adding sapanisertib to cabozantinib helps people with metastatic liver cancer that has a beta-catenin gene change.

  Recruiting at 4 sites Phase 1/2 National Cancer Institute (NCI) · Irvine, California and 3 other locations · NCT06811116

• Combining Ligufalimab and Cadonilimab for Advanced Liver Cancers

  This study is testing if combining two treatments, Ligufalimab and Cadonilimab, can help people with advanced liver cancers that haven't improved with other therapies.

  Recruiting Phase 2 University of Texas Southwestern Medical Center · Dallas, Texas · NCT06789848

• Autologous CD19 CAR-T (CNCT19) for advanced liver cancer

  This trial will try autologous CD19 CAR-T cells (CNCT19) as a treatment for adults with advanced hepatocellular carcinoma who have progressed after at least two lines of systemic therapy.

  Recruiting Phase 1 Zhejiang University · Hangzhou, Zhejiang and 1 other locations · NCT06676982

• Ablation therapy for lung metastases in advanced liver cancer

  This study tests whether a new treatment combining image-guided ablation therapy with standard care can help people with advanced liver cancer that has spread to the lungs feel better and live longer.

  Recruiting Sun Yat-sen University · Beijing, Beijing Municipality · NCT06644430

• Treatment for advanced liver cancer using new drug combinations

  This study is testing whether a new combination of drugs can help people with advanced liver cancer live longer and feel better compared to another treatment option.

  Recruiting Phase 3 Suzhou Suncadia Biopharmaceuticals Co., Ltd. · Hefei, Anhui · NCT06618664

• Combining dTACE-HAIC with Bevacizumab and Atezolizumab for treating large liver cancer

  This study is testing a new combination treatment for people with large liver cancer to see if it works better than current options for those who can't have surgery.

  Recruiting Sun Yat-sen University · Beijing, None Selected · NCT06609863

• Evaluating ALN-BCAT for liver cancer treatment

  This study is testing a new treatment called ALN-BCAT, alone and with another drug, to see if it can safely help people with advanced liver cancer.

  Recruiting at 22 sites Phase 1 Alnylam Pharmaceuticals · Phoenix, Arizona and 22 other locations · NCT06600321

• Combining atezolizumab and bevacizumab with stereotactic body radiotherapy for advanced liver cancer

  This study is testing if combining two cancer drugs with a specific type of radiation therapy can help people with advanced liver cancer feel better and improve their treatment outcomes.

  Recruiting Yonsei University · Yongin-si · NCT06595108

• Oral FMT Capsules Added to ICI-TKI Therapy in Advanced HCC After Progression

  This study tests whether adding daily oral fecal microbiota capsules to continued ICI-TKI therapy helps adults with advanced hepatocellular carcinoma whose disease progressed on the combination treatment.

  Recruiting Phase 2 Shenzhen Third People's Hospital · Shenzhen · NCT06563947

• Ablation combined with lenvatinib and PD-1 inhibitor for advanced liver cancer with limited metastases

  This study is testing if combining a targeted treatment with a special type of therapy can help people with advanced liver cancer that has spread a little, to see if it improves their chances of living longer.

  Recruiting Sun Yat-sen University · Beijing, None Selected · NCT06550921

• Combining surgery with targeted and immunotherapy for advanced liver cancer

  This study is testing whether combining surgery with targeted therapy and immunotherapy can help people with advanced liver cancer live longer and feel better.

  Recruiting Phase 1 Tongji Hospital · Wuhan, Hubei · NCT06470256

• Treatment using CAR-T cells targeting GPC3 for advanced liver cancer

  This study is testing a new type of immune cell treatment for people with advanced liver cancer to see if it is safe and helps fight the disease.

  Recruiting at 2 sites Phase 1 Zhejiang University · Hangzhou, Zhejiang and 1 other locations · NCT06461624

• Evaluating CD-801 for treating advanced liver cancer

  This study is testing a new treatment called CD-801 to see if it can safely help people with advanced liver cancer feel better and improve their outcomes.

  Recruiting Early Phase 1 Shanghai Changzheng Hospital · Shanghai, Shanghai Municipality · NCT06418659

• Combining TAE+HAIC with Camrelizumab and Apatinib for Advanced Liver Cancer

  This study is testing a new combination treatment for advanced liver cancer to see if it can help patients with high tumor loads feel better and improve their outcomes.

  Recruiting Phase 2 Fujian Medical University · Fuzhou · NCT06363825

• Testing a new drug for advanced liver cancer

  This study is testing a new drug called ETN101 to see if it can help people with advanced liver cancer who haven't had success with other treatments.

  Recruiting at 2 sites Phase 1 Etnova Therapeutics Corp. · Seoul and 1 other locations · NCT06326502

• Combining locoregional therapy with Bevacizumab and PD1/L1 inhibitors for advanced liver cancer

  This study is testing if combining a local treatment with Bevacizumab and PD1/L1 inhibitors can help people with advanced liver cancer who can’t have surgery feel better and improve their outcomes.

  Recruiting Sun Yat-sen University · Beijing, Beijing Municipality · NCT06323382

• Combining rituximab with prior therapies for advanced liver cancer

  This study is testing if adding rituximab to other treatments can help people with advanced liver cancer who haven't had success with previous therapies.

  Recruiting Phase 2 Tianjin Medical University Cancer Institute and Hospital · Tianjin, Tianjin Municipality · NCT06301399

• At-home cancer treatment versus clinic-based treatment for advanced cancer patients

  This study tests whether giving cancer treatment at home is better for comfort and satisfaction compared to getting it at a clinic for people with advanced cancer.

  Recruiting at 2 sites Phase 2 Mayo Clinic · Jacksonville, Florida and 1 other locations · NCT05969860

• Testing Tegavivint for Advanced Liver Cancer

  This study is testing a new drug called tegavivint to see if it can help people with advanced liver cancer who haven't had success with other treatments.

  Recruiting at 8 sites Phase 1/2 Iterion Therapeutics · Duarte, California and 7 other locations · NCT05797805

• Combining Lenvatinib, TACE, and Camrelizumab for Advanced Liver Cancer Treatment

  This study is testing a new combination treatment of lenvatinib, TACE, and camrelizumab to see if it helps people with advanced liver cancer live longer compared to using lenvatinib and TACE alone.

  Recruiting Phase 3 West China Hospital · Chengdu, Sichuan · NCT05738616

• Using GPC-3 CAR-T cells to treat advanced liver cancer

  This study is testing a new type of immune therapy using GPC-3 CAR-T cells to see if it can help people with advanced liver cancer who have run out of other treatment options.

  Recruiting Shenzhen University General Hospital · Shenzhen, Guangdong · NCT05620706

• Evaluating ADI-PEG 20 for patients with advanced liver cancer and high arginine levels

  This study is testing if a new treatment called ADI-PEG 20 can help people with advanced liver cancer and high arginine levels live longer and feel better compared to a placebo.

  Recruiting at 8 sites Phase 3 Polaris Group · Changhua and 10 other locations · NCT05317819

• Combining Tumor Treating Fields with Cabozantinib or Pembrolizumab and Nab-Paclitaxel for Advanced Solid Tumors

  This study is testing a new treatment that combines tumor treating fields with two different cancer drugs to see if it helps people with advanced solid tumors in the abdomen or chest.

  Recruiting Phase 1 M.D. Anderson Cancer Center · Houston, Texas · NCT05092373

• Cryoablation with Tislelizumab and Lenvatinib for Advanced Liver Cancer

  This study is testing if combining a freezing treatment with two medications can help people with advanced liver cancer feel better and live longer.

  Recruiting Phase 2 Fudan University · Shanghai, Shanghai Municipality · NCT05057845

• Radiation therapy followed by immune therapy for advanced liver cancer

  This study is testing whether a combination of radiation therapy and immune treatments can help people with advanced liver cancer that hasn't improved after other treatments.

  Recruiting Phase 2 University of California, San Francisco · San Francisco, California · NCT04430452

NIH-funded research (2)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Image-guided device to deliver immunotherapy and heat to liver tumors

  This project uses a special image-guided device to put immune-boosting medicine and controlled heat directly into liver tumors for people with advanced hepatocellular carcinoma.

  NIH research University of Tx Md Anderson Can Ctr · Houston, United States · NIH-11283934

• A device to improve immunotherapy delivery for liver cancer treatment

  This study is testing a new device called the ImFusion system that helps deliver cancer-fighting treatments directly into liver tumors while also warming the area to boost the treatment's effectiveness, aiming to provide a better and safer option for people with advanced liver cancer.

  NIH research University of Tx Md Anderson Can Ctr · Houston, United States · NIH-11031362

Related topics

Quick answers

How many Advanced Hepatocellular Carcinoma clinical trials are recruiting right now?

31, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 9 countries. The most sites are in China (17 trials), United States (12 trials), South Korea (3 trials), Canada (2 trials), Taiwan (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 9, Phase 1: 6, Phase 3: 4, Phase 1/2: 4. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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