Condition

Stage IV Hepatocellular Carcinoma AJCC v8 clinical trials and research

• 12Clinical trials
• 2Countries

Newest Stage IV Hepatocellular Carcinoma AJCC v8 clinical trials

All recruiting trials (12)

• Morning versus afternoon immunotherapy for advanced or metastatic solid tumors

  This trial tests whether giving standard immune checkpoint inhibitor therapy in the morning versus the afternoon changes outcomes for adults with advanced or metastatic solid tumors.

  Recruiting Phase 4 OHSU Knight Cancer Institute · Portland, Oregon · NCT07405086

• Celecoxib with durvalumab and tremelimumab for advanced liver cancer

  This phase II trial tests whether adding the oral drug celecoxib to the immunotherapy drugs durvalumab and tremelimumab helps people with advanced or metastatic liver cancer.

  Recruiting at 3 sites Phase 2 Emory University · Atlanta, Georgia and 3 other locations · NCT07174570

• Immunotherapy with or without targeted high-dose liver radiation (SBRT) for advanced liver cancer

  This trial will see if adding targeted high-dose liver radiation (SBRT) to standard immunotherapy helps people with advanced liver cancer that has invaded blood vessels.

  Recruiting at 139 sites Phase 3 NRG Oncology · Berkeley, California and 138 other locations · NCT07166406

• Zanzalintinib for advanced liver cancer after prior treatment

  This phase Ib/II study tests if zanzalintinib is safe and tolerable and if it can help people with advanced liver cancer after other therapies.

  Recruiting Phase 1/2 Northwestern University · Chicago, Illinois · NCT07042919

• Sapanisertib plus cabozantinib for metastatic liver cancer with beta-catenin changes

  This trial tests whether adding sapanisertib to cabozantinib helps people with metastatic liver cancer that has a beta-catenin gene change.

  Recruiting at 4 sites Phase 1/2 National Cancer Institute (NCI) · Irvine, California and 3 other locations · NCT06811116

• Personalized vaccine combined with pembrolizumab for advanced solid tumors

  This study is testing a new personalized cancer vaccine combined with pembrolizumab to see if it helps people with advanced solid tumors fight their cancer better.

  Recruiting Phase 1/2 Mayo Clinic · Jacksonville, Florida · NCT05269381

• Combining atezolizumab with a multi-kinase inhibitor for advanced liver cancer treatment

  This study is testing if adding atezolizumab to either cabozantinib or lenvatinib can help people with advanced liver cancer live longer and feel better compared to just taking the multi-kinase inhibitor alone.

  Recruiting at 10 sites Phase 2 Academic and Community Cancer Research United · Scottsdale, Arizona and 15 other locations · NCT05168163

• Combining Tumor Treating Fields with Cabozantinib or Pembrolizumab and Nab-Paclitaxel for Advanced Solid Tumors

  This study is testing a new treatment that combines tumor treating fields with two different cancer drugs to see if it helps people with advanced solid tumors in the abdomen or chest.

  Recruiting Phase 1 M.D. Anderson Cancer Center · Houston, Texas · NCT05092373

• Radiation therapy followed by immune therapy for advanced liver cancer

  This study is testing whether a combination of radiation therapy and immune treatments can help people with advanced liver cancer that hasn't improved after other treatments.

  Recruiting Phase 2 University of California, San Francisco · San Francisco, California · NCT04430452

• Using radiation therapy to treat metastatic gastrointestinal cancers

  This study tests if adding radiation therapy to immunotherapy can help people with metastatic gastrointestinal cancers feel better and improve their disease status.

  Recruiting University of California, San Francisco · San Francisco, California and 1 other locations · NCT04221893

• Using modified immune cells and a vaccine to treat unresectable liver cancer after radiation therapy

  This study is testing a new way to treat liver cancer that can't be removed by surgery by using modified immune cells and a vaccine after radiation therapy to see if it helps patients feel better.

  Recruiting Phase 1/2 Mayo Clinic · Rochester, Minnesota · NCT03942328

• Real-time imaging of tumor blood vessels during surgery

  We will test whether a real-time microscope technique during surgery can show how well blood vessels in adults' solid tumors work and whether that helps predict if systemic cancer medicines can reach the tumor.

  Recruiting Mayo Clinic · Jacksonville, Florida · NCT03823144

Related topics

Quick answers

How many Stage IV Hepatocellular Carcinoma AJCC v8 clinical trials are recruiting right now?

12, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 2 countries. The most sites are in United States (12 trials), Canada (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 1/2: 4, Phase 2: 3, Phase 1: 1, Phase 3: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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