Impact of Exercise and Statins on Cancer Treatment

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial aims to determine if supervised physical exercise during cancer drug treatment enhances the effectiveness of the treatment for patients with metastatic breast, kidney, ovarian, and prostate cancer compared to unsupervised exercise. Additionally, the study investigates whether atorvastatin, a cholesterol-lowering medication, combined with guided group exercise can further improve treatment responses. The exercise program includes both aerobic and resistance training, and the trial is randomized to ensure robust results. The study focuses on the relationship between exercise, statin use, and cancer treatment efficacy in a controlled setting.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* The patient has metastatic prostate cancer, breast cancer, ovarian cancer or kidney cancer confirmed histologically and by imaging, for which 1st-line cancer drug treatment is started
* Prostate cancer: First course of docetaxel treatment or second-generation antiandrogen treatment for metastatic prostate cancer.
* Breast cancer: First-line medical treatment of metastatic breast cancer regardless of hormone receptor status.
* Kidney cancer: Kidney cancer, for which 1st-line cancer drug treatment is started as tki monotherapy and/or IO monotherapy or as a combination therapy.
* Ovarian cancer: stage III or IV cancer for which chemotherapy treatment is started.
* The patient agrees to the study and signs a written informed consent.
* Adult (18 years=\>) women (breast, ovarian and kidney cancer) and men (prostate and kidney cancer) are recruited for the study.
* In women, the use of a reliable contraceptive during the intervention

Exclusion Criteria:

* High risk of bone fractures
* Inability to physical exertion and/or unsuitability for cancer drug treatment
* Poor co-operation ability for psychological reasons
* Active use of cholesterol-lowering drugs
* Severe liver or kidney failure
* Troublesome side effects that occurred in the past during cholesterol medication
* Continuous use of medicinal substances that interact with atorvastatin during the study period
* A special group of subjects according to the EU Clinical Trials Regulation 536/2014 (e.g. pregnant or lactating women)

Exclusion criteria in patients who are already using statin medication before the study:

* High risk of bone fractures
* Inability to physical exertion and/or unsuitability for cancer drug treatment
* Poor co-operation ability for psychological reasons
* Severe liver or kidney failure
* A special group of subjects according to the EU Clinical Trials Regulation 536/2014 (e.g. pregnant or lactating women)

Where it's running

• Tampere University Hospital
  Tampere, Länsi-Suomi, Finland Recruiting

Study contacts

• Principal investigator: Teemu Murtola, MD PhD Prof — Tampere University Hospital
• Study coordinator: Teemu Murtola, MD PhD Prof
• Email: teemu.murtola@tuni.fi
• Phone: 03-311611

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.