Improving care for patients with advanced lung cancer using personalized approaches
Official title: Optimizing Supportive Care for Patients with Metastatic Lung Cancer in the Era of Precision Oncology
Funded at Massachusetts General Hospital · NIH-10910885 · Data updated 2026-11-12
This study is looking to improve support for people with metastatic lung cancer who have certain genetic mutations by testing a new way to help them feel more comfortable and make better decisions about their care, based on what they and their doctors think is important.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | June 1, 2022 |
| Project end | August 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $271,934 |
| NIH project number | 5K08CA263549-03 |
| Project ID | NIH-10910885 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with metastatic lung cancer who have targetable oncogenic driver mutations.
✕Less likely to help
Patients with early-stage lung cancer or those without specific genetic mutations may not benefit from this research.
What this research studies
This research focuses on enhancing supportive care for patients with metastatic lung cancer, particularly those with specific genetic mutations. It aims to develop and test a new palliative care intervention that addresses the unique needs of these patients, helping them manage uncertainty about their prognosis and make informed decisions about their care. The study will involve refining the intervention based on feedback from patients and healthcare providers, followed by a pilot test to evaluate its feasibility and acceptability compared to standard care. Ultimately, the goal is to improve patients' quality of life and their ability to discuss their preferences for care.
Why it matters
Potential benefit: If successful, this research could significantly improve the quality of life and decision-making processes for patients with metastatic lung cancer.
How similar studies have gone: Previous research has shown promising results in improving supportive care for cancer patients through tailored interventions, suggesting this approach may be effective.
Where this research is happening
-
Massachusetts General Hospital
Boston, United States Active
Researchers
- Principal investigator: Petrillo, Laura Anne — Massachusetts General Hospital
- Study coordinator: Petrillo, Laura Anne
Related research
Other NIH-funded projects on the same topics.
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ECM-targeted theranostic treatment for metastatic lung cancer
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Targeted T cell therapy for metastatic lung cancer with mutated KRAS
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-
Supportive Care for Lung Cancer Patients with Targeted Therapy
A patient-facing program tests a palliative care approach tailored for people living with oncogene-driven metastatic lung cancer to help with uncertainty, self-care, and discussions about goals and values.
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LiveWell — DBT skills training for people living with metastatic lung cancer
This is an eight-session, one-on-one online program that teaches Dialectical Behavior Therapy skills to help people living with metastatic lung cancer handle distress, symptoms, and relationships.
-
Engineered T cells that target KRAS-mutated metastatic lung cancer
This project uses specially engineered immune cells to try to find and kill metastatic lung cancers that have KRAS gene mutations.
-
Using aerosolized therapy to treat metastatic lung cancer
This study is exploring a new way to treat metastatic lung cancer by using a special inhaled therapy that may help wake up genes in cancer cells, and it's designed for patients looking for more effective treatment options.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.