Condition

Metastatic Non Small Cell Lung Cancer clinical trials and research

• 20Clinical trials
• 48Countries

Newest Metastatic Non Small Cell Lung Cancer clinical trials

All recruiting trials (20)

• DS-3939a in solid tumors and non-small cell lung cancer

  This study tests DS-3939a, alone or with other anticancer drugs, in adults with solid tumors including locally advanced or metastatic NSCLC to see if it is safe and helps control the disease.

  Recruiting at 3 sites Phase 1/2 Daiichi Sankyo · Fayetteville, Arkansas and 75 other locations · NCT07739966

• Safety and activity of radioligand therapy with RTX-2358 plus immune therapy in FAP-positive metastatic NSCLC

  A small, early study tests whether giving a targeted radioligand to patients with FAP-positive metastatic NSCLC, combined with a PD-1 inhibitor, is safe and shows signs of activity.

  Recruiting Early Phase 1 Union Hospital, Tongji Medical College, Huazhong University of Science and Technology · Wuhan, Hubei · NCT07689643

• PF-08634404 plus chemotherapy versus pembrolizumab-based chemotherapy for advanced non-small cell lung cancer

  This will test whether PF-08634404 combined with chemotherapy works better than pembrolizumab plus chemotherapy for adults with locally advanced or metastatic non-small cell lung cancer who have not received prior treatment for their advanced disease.

  Recruiting at 464 sites Phase 3 Pfizer · Bullhead City, Arizona and 483 other locations · NCT07222566

• Firmonertinib versus standard EGFR drugs as first treatment for advanced NSCLC with EGFR PACC mutations

  This trial tests whether daily firmonertinib works better than standard EGFR drugs (osimertinib or afatinib) as the first treatment for people with advanced NSCLC that has EGFR PACC mutations.

  Recruiting at 141 sites Phase 3 ArriVent BioPharma, Inc. · Fullerton, California and 140 other locations · NCT07185997

• Ubamatamab with or without REGN7075 for adults with advanced or metastatic non-small cell lung cancer

  This trial will try ubamatamab alone and with REGN7075 in adults with advanced or metastatic non-small cell lung cancer to see if they control the cancer and will try sarilumab to manage immune-related side effects.

  Recruiting at 18 sites Phase 2 Regeneron Pharmaceuticals · Birmingham, Alabama and 17 other locations · NCT07154290

• MOv19-BBz CAR T cell treatment for FRa-positive lung cancer

  This trial will test whether a single intrapleural infusion of MOv19-BBz CAR T cells given after lymphodepleting chemotherapy is safe and can help control FRa-positive metastatic or recurrent non-small cell lung cancer with malignant pleural effusion.

  Recruiting Phase 1 University of Pennsylvania · Philadelphia, Pennsylvania · NCT07116057

• Collecting blood and viable tumor samples from people with oncogene-driven or neoadjuvantly treated non-small cell lung cancer.

  This project will try to see if paired blood and viable tumor samples can be reliably collected from adults with oncogene-driven advanced NSCLC starting targeted therapy and from adults with stage II–III NSCLC receiving neoadjuvant immunotherapy.

  Recruiting Royal Marsden NHS Foundation Trust · London, United Kingdom · NCT07008742

• Morning vs Flexible Timing Pembrolizumab in Metastatic Non-Small Cell Lung Cancer

  This study tests whether giving pembrolizumab in the morning is better or the same as standard timing for people with metastatic non-small cell lung cancer who are eligible for this treatment.

  Recruiting Phase 2 AHS Cancer Control Alberta · Edmonton, Alberta · NCT06882174

• Reduced chemotherapy and immunotherapy for older adults with advanced lung cancer

  This study is testing a lower dose of chemotherapy combined with immunotherapy to see if it's safe and tolerable for older adults over 70 with advanced lung cancer who can’t have curative treatment.

  Recruiting at 2 sites Phase 2 Virginia Commonwealth University · Richmond, Virginia and 1 other locations · NCT06731413

• Using Stereotactic Body Radiotherapy for treating metastatic lung cancer with limited progression

  This study is testing if adding a special type of radiation therapy to standard treatment can help people with advanced lung cancer live longer and feel better after their first round of chemotherapy.

  Recruiting Phase 3 Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang · NCT06523673

• Probiotic effects on treatment response in lung cancer patients

  This study is testing whether a probiotic supplement can help lung cancer patients on immunotherapy respond better to their treatment.

  Recruiting Necmettin Erbakan University · Konya · NCT06428422

• Evaluating BBO-8520 for treating KRAS G12C non-small cell lung cancer

  This study is testing a new drug called BBO-8520 to see if it can safely help adults with a specific type of lung cancer that has a KRAS G12C mutation, both on its own and when combined with another treatment.

  Recruiting at 38 sites Phase 1 TheRas, Inc., d/b/a BBOT (BridgeBio Oncology Therapeutics) · Birmingham, Alabama and 37 other locations · NCT06343402

• Using electric fields with immunotherapy and chemotherapy for advanced lung cancer

  This study is testing whether using electric fields along with immunotherapy and chemotherapy can help people with advanced lung cancer live longer and feel better compared to standard treatments alone.

  Recruiting at 107 sites Phase 3 NovoCure Ltd. · Birmingham, Alabama and 106 other locations · NCT06216301

• Testing lower doses of atezolizumab for cancer treatment

  This study is testing whether lower doses of atezolizumab can effectively treat adults with advanced cancer while causing fewer side effects.

  Recruiting Phase 1 National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT06066138

• Investigating OBX-115 for advanced solid tumors

  This study is testing a new treatment called OBX-115 to see if it can help adults with advanced solid tumors like metastatic melanoma and non-small cell lung cancer feel better and live longer.

  Recruiting at 13 sites Phase 1/2 Obsidian Therapeutics, Inc. · Tucson, Arizona and 13 other locations · NCT06060613

• Using breath tests to predict response to lung cancer immunotherapy

  This study is testing if measuring a gas in your breath can help doctors predict how well lung cancer patients will respond to a specific immunotherapy treatment.

  Recruiting Centre Hospitalier Universitaire Dijon · Dijon · NCT05985330

• Comparing maintenance therapy with radiation for lung cancer patients with limited metastases

  This study is testing if adding radiation therapy to standard treatment can help lung cancer patients with a few spots of cancer live better and longer.

  Recruiting Phase 3 Tata Memorial Hospital · Mumbai, Maharashtra · NCT05278052

• Using autologous LN-145 cell therapy for metastatic non-small-cell lung cancer

  This study is testing a new treatment using patients' own immune cells to see if it can help people with advanced non-small-cell lung cancer feel better.

  Recruiting at 65 sites Phase 2 Iovance Biotherapeutics, Inc. · Gilbert, Arizona and 70 other locations · NCT04614103

• Treatment for advanced lung cancer with KRAS G12C mutation

  This study is testing a new treatment called adagrasib, alone and with another drug called pembrolizumab, to see if it helps people with advanced lung cancer that has a specific mutation.

  Recruiting at 382 sites Phase 2/3 Mirati Therapeutics Inc. · Goodyear, Arizona and 769 other locations · NCT04613596

• Comparing osimertinib alone versus with chemotherapy for lung cancer

  This study is testing whether adding chemotherapy to osimertinib can help people with advanced lung cancer and an EGFR mutation feel better and live longer.

  Recruiting at 15 sites Phase 2 Memorial Sloan Kettering Cancer Center · Sacramento, California and 17 other locations · NCT04410796

Related topics

Quick answers

How many Metastatic Non Small Cell Lung Cancer clinical trials are recruiting right now?

20, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 48 countries. The most sites are in United States (12 trials), France (7 trials), Canada (7 trials), China (6 trials), Italy (6 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 5, Phase 3: 5, Phase 1: 3, Phase 1/2: 2. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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