Targeting Skeletal Muscle to Help MASLD

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This single-site interventional study will enroll adults with MASLD and excess muscle lipid content to see how high-, moderate-, and low-intensity exercise affect muscle fat and liver disease severity. Participants will follow structured aerobic programs, and outcomes will include imaging measures of muscle fat and liver health, along with possible mechanisms of benefit. The study aims to clarify whether skeletal muscle changes from exercise can contribute to MASLD improvement and what drives those effects. Results could inform exercise prescriptions for MASLD management.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* confirmed MASLD at abdominal imaging
* confirmed excessive muscle lipid content at imaging
* stable weight

Exclusion Criteria:

* severe comorbidities including active malignancies, neuromuscular degenerative diseases
* contraindications to physical activity
* excessive alcohol consumption

Where it's running

• Cliniques universitaires Saint-Luc
  Brussels, Belgium Recruiting
• Centre d'investigation clinique en nutrition
  Louvain-la-Neuve, Belgium Recruiting

Study contacts

• Principal investigator: Nicolas Lanthier, MD, PhD — Cliniques universitaires Saint-Luc- Université Catholique de Louvain
• Study coordinator: Guillaume Henin, MD, PhD student
• Email: guillaume.henin@uclouvain.be
• Phone: 0032494312548

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Endohepatology-based reclassification of treatment indication in high-risk MASLD

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• ALN-CIDEB in adults with MASLD to see if it helps the liver

  This study tests whether ALN-CIDEB can help adults with MASLD and its liver damage compared to placebo.

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• Liver Fat and Scarring in People Suspected of Non-Celiac Wheat Sensitivity

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  Recruiting at 2 sites University of Palermo · Palermo, Palermo and 1 other locations · NCT07750535

• Taiwan green propolis for MASLD and lipid/metabolic issues

  This study tests whether Taiwan green propolis capsules can improve blood lipids and body fat in adults with MASLD compared to a placebo over 12 weeks.

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• Secukinumab retention in adults with plaque psoriasis and MASLD in Spain

  This study tests how long people with plaque psoriasis and MASLD stay on secukinumab in real-world Spain, using EMR data from several hospitals.

  Recruiting at 9 sites Novartis · Badalona, Barcelona and 8 other locations · NCT07683065

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.