Taiwan green propolis for MASLD and lipid/metabolic issues

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a double-blind, randomized, placebo-controlled trial enrolling up to 60 adults with MASLD at Dalin Tzu Chi Hospital in Taiwan. Participants take four capsules daily (two before breakfast and two before dinner) for 12 weeks, with random assignment to propolis or placebo and blinding of participants and researchers. The study assesses changes in blood lipids, liver enzymes, glucose metabolism, inflammatory markers, and body composition, among other health indicators, at baseline and after the intervention. Allocation uses computer-generated randomization with stratification by life stage and concealment via opaque envelopes. Primary outcomes focus on lipid and metabolic profiles to see if propolis offers additional benefit beyond standard care.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adults aged 18 to 80 years
* Diagnosis of hepatic steatosis (fatty liver) confirmed by abdominal ultrasound, PLUS at least one of the following metabolic risk factors:

  1. Overweight or obesity: BMI \>= 23 kg/m\^2
  2. Elevated waist circumference: \>= 90 cm in men or \>= 80 cm in women (South Asian and Chinese criteria)
  3. Dysglycemia or type 2 diabetes: prediabetes (HbA1c 5.7-6.4%, or fasting glucose 100-125 mg/dL, or OGTT 2-hour glucose 140-199 mg/dL) OR type 2 diabetes (HbA1c \>= 6.5%, or fasting glucose \>= 126 mg/dL, or OGTT 2-hour glucose \>= 200 mg/dL, or current pharmacological treatment for type 2 diabetes)
  4. Elevated triglycerides: \>= 150 mg/dL or currently on lipid-lowering therapy
  5. Low HDL-C: \<= 39 mg/dL in men or \<= 50 mg/dL in women, or currently on lipid-lowering therapy
  6. Elevated blood pressure: \>= 130/85 mmHg or currently on antihypertensive treatment

Exclusion Criteria:

* Known allergy to honey, propolis, multiple pollens, or alcohol
* Psychiatric disorder or cognitive impairment
* Currently pregnant or breastfeeding
* Significant endocrine abnormality, or major disease of the heart, liver (other than MASLD), or kidney
* Difficulty swallowing capsules
* Dementia, impaired consciousness, or inability to respond to questionnaires

Where it's running

• Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation
  Dalin, Taiwan Recruiting

Study contacts

• Study coordinator: Tsai-Wei Huang, PhD
• Email: tsaiwei@tmu.edu.tw
• Phone: +886227361661

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Kodo Millet Porridge and Gut Health in Overweight and Obese Adults

  This study tests whether daily intake of Kodo millet porridge for 12 weeks can improve gut bacteria and metabolic health in adults who are overweight or obese.

  Recruiting Jss Medical College, Jss Academy of Higher Education and Research · Mysore, Karnataka · NCT07703371

• Automated Passive Case-Finding for Advanced Liver Fibrosis in MASLD

  This program automatically screens high‑risk adults aged 50–75 in primary care to see if they have advanced liver fibrosis and possible MASLD, using routine blood tests and reflex lab tests without extra work for clinicians.

  Recruiting Hospital General Universitario Gregorio Marañon · Madrid, Madrid · NCT07658755

• Personalized daily step targets to change body fat and cardiometabolic risk in adults with overweight or obesity

  This project will test if giving personalized daily step targets based on body fat helps adults with overweight or obesity change body composition and lower cardiometabolic risk.

  Recruiting Kennesaw State University · Kennesaw, Georgia · NCT07221279

• How incretin treatments affect muscle mass and function in people with overweight or obesity

  This study will see how drugs like semaglutide and tirzepatide influence fat-free mass, muscle strength, and physical function in adults with overweight or obesity.

  Recruiting Radboud University Medical Center · Amsterdam and 1 other locations · NCT07929831

• Dose find for remimazolam plus alfentanil for gastroscopy in obese adults

  This trial tests what dose of remimazolam besylate with alfentanil best sedates obese adults during gastroscopy.

  Recruiting Qianfoshan Hospital · Jinan, Shandong · NCT07925684

• Observational study of achieving LDL targets with Rovazet tablets in dyslipidemia

  This study follows patients with dyslipidemia who are prescribed Rovazet to see how well reaching LDL targets works in routine care over 48 weeks.

  Recruiting HK inno.N Corporation · Seoul · NCT07924345

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.