Belief Update in Depression and Antidepressants in Older Adults
Official title: Belief Update: The Effects of Depression and Antidepressants in Older People
Run by Hospital Center Guillaume Régnier · NCT07681492 · Data updated 2026-11-12
This study tests whether antidepressants change how older adults with major depressive disorder view the future and whether those belief changes relate to mood improvement.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 65 Years and up |
| Sex | All |
| Enrollment | 62 (estimated) |
| Sponsor | Hospital Center Guillaume Régnier Academic / other |
| Locations | 2 sites (Rennes and 1 other locations) |
| Status | Recruiting |
| Started | January 14, 2025 |
| Main results expected | October 2027 |
| Study ends | October 2027 |
| Registry record updated | July 2, 2026 |
| Trial ID | NCT07681492 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Outpatients over 65 with major depressive disorder (or bipolar major depressive disorder as evaluated by MINI), without cognitive impairment (MMSE ≥ 24) and MADRS ≥ 20, who are changing antidepressants.
✕Probably not a fit
Patients with significant cognitive impairment, non-depressive primary disorders, or those not undergoing a change in antidepressants may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This interventional study investigates how antidepressant treatment affects beliefs about the future in people over 65 with major depressive disorder. Participants complete questionnaires to assess belief changes and mood symptoms before and after changing antidepressants. The aim is to see if shifts in outlook accompany symptom improvement and whether expectations influence outcomes. The study uses a questionnaire-driven approach to capture subjective beliefs and their association with treatment response in an outpatient setting.
Why it matters
Potential benefit: If successful, findings could help tailor antidepressant strategies by considering patients’ beliefs and expectations to maximize mood improvement in older adults.
How similar studies have gone: Previous research suggests beliefs and expectations can influence treatment outcomes, but this study adds a specific focus on elderly patients and antidepressant-related belief changes.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria for patients with major depressive disorder : * Patient over 65 years old in outpatient care * Patients with major depressive disorder or patients with bipolar major depressive disorder as evaluated by the Mini International Neuropsychiatric Interview (MINI) semi-structured interview for the group suffering from depression * Absence of cognitive impairment as evidenced by an MMSE (Mini Mental State Examination) ≥ 24 * MADRS ≥ 20 * MMSE ≥ 24 * Change of antidepressants * Person affiliated with a social security scheme * Patients who have received informed information about the study and have signed a consent form to participate in the study Exclusion Criteria with major depressive disorder : * mental disorders other than mood disorders : attention deficit dissorder, borderline personality disorder, schizophrenia, autism spectrum disorder, anorexia-bulimia disorder, obsessive-compulsive disorder, anxiety disorders and substance use disorder (except tobacco). * Inability to understand task instructions and perform the behavioral task * Neurological or neurosurgical comorbidities * Major visual impairment * Adults under state medical aid * Adults under legal protection (legal guardianship, curatorship, trusteeship), persons deprived of their liberty Inclusion Criteria for patients with major depressive disorder : * Absence of psychiatric disorders attested by administration of the MINI * Absence of cognitive impairment as evidenced by an MMSE ≥ 24
Where it's running
-
Centre Hospitalier Guillaume Régnier
Rennes, France Recruiting -
Centre Hospitalier Guillaume Regnier
Rennes, France Not yet recruiting
Study contacts
- Study coordinator: Gabriel ROBERT, PhD
- Email: g.robert@ch-guillaumeregnier.fr
- Phone: +332 99 33 39 37
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.