Tart cherry and fish oil for aromatase inhibitor–related joint pain

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This early-phase interventional project gives participants tart cherry concentrate, fish oil, or a combination over a 12-week period to measure changes in joint function and pain. Enrollment targets women with stage I–III breast cancer who are actively receiving aromatase inhibitor therapy and meet specified criteria (including BMI ≥27, Omega-3 index <8%, and average joint pain ≥4). Outcomes will focus on patient-reported joint pain and stiffness, with biochemical and functional measures used as secondary endpoints. The work is conducted at Cedars-Sinai sites in Los Angeles and Torrance, California.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Breast cancer diagnosis (Stage I-III) with any hormonal status.
* Females aged ≥ 18 years.
* Currently receiving AI therapy.
* BMI ≥ 27.
* Clinical diagnosis of AIMSS.
* Omega-3 Index \<8%.
* Average joint pain score ≥ 4 on the Brief Pain Inventory (BPI) within 7 days of enrollment.
* Written informed consent obtained from subject and ability and willingness of subject to comply with the requirements of the study.

Exclusion Criteria:

* Current use of anticoagulant medications (Including but not limited to Warfarin, Lovenox, Eliquis, Xarelto).
* Allergy to cherries or fish/fish products.
* Lifetime history of rheumatoid arthritis and/or inflammatory joint diseases (Including but not limited to reactive arthritis, ankylosing spondylitis, and psoriatic arthritis).
* Uncontrolled diabetes mellitus as determined by treating physician (with or without the use of glucose lowering medications and/or insulin).
* Lifetime history of stroke or transient ischemic attacks.
* New use or dose change of oral or topical analgesics in the previous 14 days. (Including but not limited to opioids, non-steroidal anti-inflammatories, acetaminophen, SNRI's, SSRI's, gabapentinoids, tricyclic antidepressants, and muscle relaxants).
* Oral or intra-articular steroid use in the previous 30 days (Including but not limited to dexamethasone, prednisone, methylprednisolone, triamcinolone, hydrocortisone).
* History of joint fracture or surgery of the symptomatic joint in the previous 6 months.

Where it's running

• Cedars-Sinai Medical Center
  Los Angeles, California, United States Recruiting
• CS Cancer at the Hunt Cancer Center
  Torrance, California, United States Not yet recruiting

Study contacts

• Principal investigator: Philip Chang, DO — Cedars-Sinai Medical Center
• Study coordinator: Clinical Trial Navigator
• Email: GroupCancerTrialInformation@cshs.org
• Phone: 310-423-5842

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.