Condition

Ischemic Cardiomyopathy clinical trials and research

• 17Clinical trials
• 7NIH research projects
• 7Countries

Newest Ischemic Cardiomyopathy clinical trials

All recruiting trials (17)

• HB1011: a first-in-human test of heart-derived stem cells injected during bypass surgery

  This study tests whether a heart-derived stem cell therapy called HB1011 is safe to use during CABG surgery for people with ischemic cardiomyopathy.

  Recruiting Phase 1 HieraBio Inc. · Seongnam-si, Gyeonggi-do · NCT07861035

• Targeted ablation to block scar channels that cause ventricular tachycardia

  This study tests whether targeted radiofrequency ablation of scar-channel exits can prevent ventricular tachycardia in patients with scarred hearts.

  Recruiting New York Medical College · Valhalla, New York · NCT07814079

• Safety and better outcomes with FAP-targeted immunosuppressive dendritic cells in ischemic heart failure

  This trial tests whether a patient's own FAP-targeted immunosuppressive dendritic cells can be safely given alongside standard care to help people with ischemic cardiomyopathy.

  Recruiting Phase 1 Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang / 浙江 · NCT07505199

• PET imaging with XTR003 and 18F-FDG to find recoverable heart muscle in ischemic cardiomyopathy

  This trial tests whether adding XTR003 injection to 18F‑FDG PET scans helps identify living heart muscle in adults (18–85) with ischemic cardiomyopathy who are candidates for complete revascularization.

  Recruiting Phase 2 Sinotau Pharmaceutical Group · Beijing, Beijing Municipality and 2 other locations · NCT07443696

• 18F-mFBG imaging to map heart nerve signals in people with ischemic heart failure and ICDs

  Researchers are testing whether 18F-mFBG PET imaging can see heart nerve activity in people with ischemic heart failure and an ICD.

  Recruiting Phase 2 Innervate Radiopharmaceuticals LLC (Formerly: Illumina Radiopharmaceuticals LLC) · Houston, Texas · NCT06965621

• Guided PCI to restore heart pumping in ischemic cardiomyopathy

  This trial will test whether physiology- and imaging-guided PCI plus optimal medical therapy helps people with ischemic cardiomyopathy and multivessel disease improve left ventricular pumping better than medicines alone.

  Recruiting Seoul National University Hospital · Seoul, Chongno-gu · NCT06930092

• Using radiotherapy to treat advanced heart failure

  This study is testing if a single low dose of radiation therapy can help people with advanced heart failure feel better and improve their heart function.

  Recruiting Universitaire Ziekenhuizen KU Leuven · Leuven · NCT06661876

• Ablation Index-guided treatment for ventricular tachycardia in heart disease patients

  This study tests whether using a new technology to guide heart procedures can help people with heart disease and fast heartbeats feel better and have fewer problems later on compared to standard methods.

  Recruiting Rush University Medical Center · Chicago, Illinois and 4 other locations · NCT06138873

• Personalized risk prediction for functional mitral regurgitation using cardiac imaging

  This study is testing if advanced heart imaging can help predict how well patients with functional mitral regurgitation will respond to treatment.

  Recruiting The Cleveland Clinic · Cleveland, Ohio · NCT05965258

• Comparing two methods of catheter ablation for ventricular tachycardia in heart disease patients

  This study is testing if a new way of doing heart surgery can help people with heart disease and ventricular tachycardia feel better and have fewer heart rhythm problems compared to the usual method.

  Recruiting at 4 sites Rennes University Hospital · Bordeaux and 11 other locations · NCT05888662

• Comparing revascularization and medical treatment for heart failure with reduced ejection fraction

  This study is testing if opening blocked arteries with a procedure helps people with heart failure feel better compared to just taking medication.

  Recruiting Samsung Medical Center · Seoul · NCT05828719

• Comparing Biventricular Pacing and Left Bundle Branch Pacing for Heart Failure

  This study is testing whether a new way of pacing the heart can help people with heart failure feel better and improve their heart function compared to the standard method.

  Recruiting Tomsk National Research Medical Center of the Russian Academy of Sciences · Tomsk · NCT05769036

• Improving heart failure treatment for patients who don't respond to standard therapy

  This study is testing a new heart treatment using a special device for people with heart failure who haven't felt better with standard therapies, to see if it can improve their heart function and overall health.

  Recruiting Tomsk National Research Medical Center of the Russian Academy of Sciences · Tomsk · NCT05760924

• Transplanting heart tissue to aid recovery after heart surgery

  This study is testing if using small pieces of heart tissue from patients' own hearts during surgery can help them heal better and improve heart function after dealing with heart disease and heart failure.

  Recruiting Hospital District of Helsinki and Uusimaa · Helsinki, Uusimaa · NCT05632432

• Using venous ethanol to improve treatment for ventricular tachycardia

  This study is testing if adding venous ethanol to standard heart treatment can help people with ventricular tachycardia feel better and reduce their chances of having problems in the future.

  Recruiting Phase 2 The Methodist Hospital Research Institute · Houston, Texas · NCT05511246

• Registry for patients receiving implantable cardioverter defibrillators

  This study is collecting information from hospitals about patients who receive implantable defibrillators to see how well these devices are helping people and to improve care for future patients.

  Recruiting American College of Cardiology · Washington D.C., District of Columbia · NCT01999140

• Identifying heart structure predictors of sudden cardiac death

  This study is trying to see if certain heart structure problems can help predict the risk of sudden cardiac death in patients with weak heart function who may need a defibrillator.

  Recruiting Johns Hopkins University · Newark, Delaware and 1 other locations · NCT01076660

NIH-funded research (7)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Biological treatment to reduce ventricular arrhythmias in a pig model of heart disease

  Aims to test if delivering heart-cell–derived exosomes into damaged heart tissue can reduce scar and prevent dangerous ventricular rhythms in a porcine model of chronic ischemic cardiomyopathy.

  NIH research Cedars-Sinai Medical Center · Los Angeles, United States · NIH-11402761

• Correcting cardiac microdomains to reverse non-ischemic heart failure

  A gene therapy approach targeting calcium-handling microdomains in the heart is being tested to restore heart function in a large animal model of non-ischemic cardiomyopathy.

  NIH research Utah State Higher Education System--University of Utah · Salt Lake City, United States · NIH-11330515

• Better defining non-ischemic cardiomyopathy with functional mitral regurgitation to predict treatment outcomes

  The team will use advanced heart MRI to better classify people with non-ischemic cardiomyopathy and functional mitral regurgitation so doctors can predict which treatments may work best.

  NIH research Cleveland Clinic Lerner Com-Cwru · Cleveland, United States · NIH-11319841

• Repairing damaged heart tissue to stop dangerous ventricular rhythms after ischemic heart damage

  The team is testing whether tiny particles from heart-derived cells can repair scarred heart tissue and stop life-threatening ventricular rhythms in people with ischemic cardiomyopathy.

  NIH research Cedars-Sinai Medical Center · Los Angeles, United States · NIH-11168680

• Improving heart function by correcting calcium handling in heart cells

  This study is testing a new gene therapy that aims to fix how heart cells manage calcium in people with non-ischemic cardiomyopathy, using minipigs to see if improving a specific protein can help the heart work better and stay healthier.

  NIH research University of Utah · Salt Lake City, United States · NIH-11077253

• Improving treatment predictions for heart patients with mitral valve issues

  This study is looking at how to better understand and treat heart problems in people with non-ischemic cardiomyopathy and leaky heart valves, using advanced imaging techniques to help doctors choose the best treatments for each patient.

  NIH research Cleveland Clinic Lerner Com-Cwru · Cleveland, United States · NIH-11073111

• Improving heart tissue to prevent dangerous heart rhythms

  This study is looking at a new way to help people with chronic heart issues by using tiny particles from heart cells to improve the heart's electrical signals and reduce scar tissue, making it safer and more effective for patients with dangerous heart rhythms.

  NIH research Cedars-Sinai Medical Center · Los Angeles, United States · NIH-10906259

Related topics

Quick answers

How many Ischemic Cardiomyopathy clinical trials are recruiting right now?

17, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 7 countries. The most sites are in United States (7 trials), South Korea (3 trials), Russia (2 trials), China (2 trials), Finland (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 3, Phase 1: 2. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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