Improving heart function by correcting calcium handling in heart cells
Correcting Cardiac Microdomains Reverses Non-Ischemic Cardiomyopathy
This study is testing a new gene therapy that aims to fix how heart cells manage calcium in people with non-ischemic cardiomyopathy, using minipigs to see if improving a specific protein can help the heart work better and stay healthier.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Utah NIH-funded |
| Lab location | 1 site (Salt Lake City, United States) |
| Project ID | NIH-11077253 on NIH RePORTER |
What this research studies
This research investigates a new gene therapy approach aimed at correcting the calcium handling mechanisms in heart cells affected by non-ischemic cardiomyopathy. The study focuses on a protein called cBIN1, which is crucial for maintaining the structure of calcium-regulating microdomains in heart cells. By using a minipig model, researchers will explore how restoring these microdomains can improve heart function and cellular health. The methodology includes advanced biochemical and imaging techniques to assess changes in heart cell structure and function.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with non-ischemic cardiomyopathy who may benefit from advanced therapeutic options.
Not a fit: Patients with ischemic cardiomyopathy or those who do not have heart failure may not receive benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments that significantly improve heart function in patients with non-ischemic cardiomyopathy.
How similar studies have performed: Previous studies have shown promising results with similar gene therapy approaches in animal models, indicating potential for success in this novel application.
Where this research is happening
Salt Lake City, United States
- University of Utah — Salt Lake City, United States (Active)
Researchers
- Principal investigator: Shaw, Robin M — University of Utah
- Study coordinator: Shaw, Robin M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.