Improving heart tissue to prevent dangerous heart rhythms
Biological substrate modification to suppress ventricular arrhythmias in a porcine model of chronic ischemic cardiomyopathy
This study is looking at a new way to help people with chronic heart issues by using tiny particles from heart cells to improve the heart's electrical signals and reduce scar tissue, making it safer and more effective for patients with dangerous heart rhythms.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cedars-Sinai Medical Center NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-10906259 on NIH RePORTER |
What this research studies
This research investigates a new approach to prevent dangerous heart rhythms in patients with chronic ischemic cardiomyopathy. Instead of destroying heart tissue that conducts electrical signals slowly, the study aims to enhance the viability of this tissue using exosomes derived from heart progenitor cells. These exosomes are injected into specific areas of the heart identified as problematic, with the goal of reducing scar tissue and improving heart function. The research will also explore different delivery methods to make the treatment more applicable in clinical settings.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with chronic ischemic cardiomyopathy who are at risk for ventricular arrhythmias.
Not a fit: Patients with non-ischemic cardiomyopathy or those who do not have ventricular arrhythmias may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to a novel treatment that significantly reduces the risk of life-threatening heart rhythms in cardiomyopathy patients.
How similar studies have performed: Preliminary data from similar approaches have shown promise in reducing arrhythmias, indicating potential for success in this novel method.
Where this research is happening
Los Angeles, United States
- Cedars-Sinai Medical Center — Los Angeles, United States (Active)
Researchers
- Principal investigator: Dawkins, James F. — Cedars-Sinai Medical Center
- Study coordinator: Dawkins, James F.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.