Correcting cardiac microdomains to reverse non-ischemic heart failure

Who could benefit from this research

What this research studies

This project tests a gene therapy strategy aimed at rebuilding the tiny structures that control calcium signaling in heart cells, which often become defective in heart failure. Researchers will use a minipig model of pacing-induced heart failure to see if delivering cBIN1 can restore microdomain organization and improve heart function. They will combine biochemical analyses and advanced imaging to understand how the therapy affects cardiomyocyte structure and calcium handling. If successful, this work could pave the way for translating a promising therapy toward human trials for non-ischemic heart failure.

Why it matters

Where this research is happening

• Utah State Higher Education System--University of Utah
  Salt Lake City, United States Active

Researchers

• Principal investigator: Shaw, Robin M — Utah State Higher Education System--University of Utah
• Study coordinator: Shaw, Robin M

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About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.