Using radiotherapy to treat advanced heart failure

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the effects of a single low dose of whole heart external beam radiotherapy (EBRT) on patients with advanced refractory heart failure. The treatment involves administering 5 Gray of EBRT to assess its efficacy in improving left ventricular ejection fraction (LVEF) by at least 5%. The study will also evaluate safety, overall survival, hospital admissions, late toxicity, quality of life, and other heart function indicators. Participants must have stable heart failure and meet specific eligibility criteria.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patient ≥ 18 years
* Advanced refractory HF NYHA class II, III or IV
* Stable HF for the last 6 months with maximal guideline-directed HF therapy
* Ischemic or dilated cardiomyopathy
* LVEF at baseline ≤ 35%
* Ability to give a written informed consent and willingness to return for follow-up

Exclusion Criteria:

* Eligible or in consideration for heart transplantation
* Pregnancy or breastfeeding
* Previous radiotherapy with cardiac involvement
* Any condition that is deemed a contraindication in the judgment of the investigators

Where it's running

• UZ Leuven
  Leuven, Belgium Recruiting

Study contacts

• Study coordinator: Patrick Berkovic, MD PhD
• Email: patrick.berkovic@uzleuven.be
• Phone: +32 16 34 51 15

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.