Condition

Intrahepatic Cholangiocarcinoma clinical trials and research

• 35Clinical trials
• 11NIH research projects
• 11Countries

Newest Intrahepatic Cholangiocarcinoma clinical trials

All recruiting trials (35)

• HAIC plus QL1706 and bevacizumab as first-line therapy for unresectable HER2-negative intrahepatic cholangiocarcinoma

  This study tests a liver-directed chemotherapy plus immune therapy and a blood vessel blocker to see if it helps people with unresectable intrahepatic cholangiocarcinoma.

  Recruiting Phase 2 Sun Yat-sen University · Guangzhou, Guangdong · NCT07841574

• Durvalumab plus histotripsy for intrahepatic cholangiocarcinoma

  This study tests whether adding histotripsy to ongoing durvalumab helps people with advanced intrahepatic cholangiocarcinoma by boosting the immune response and checking safety.

  Recruiting Phase 2 University of Wisconsin, Madison · Madison, Wisconsin · NCT07766187

• Dual-target HER2/CEA CAR-NK Cells in Advanced Biliary Tract Cancer

  This trial tests a ready-to-use CAR-NK cell therapy that targets HER2 and CEACAM5 in adults with unresectable or metastatic biliary tract cancers after standard therapy to see if it can help control the disease.

  Recruiting Phase 1/2 Beijing Biotech · Shenzhen, Guangdong · NCT07641036

• Chidamide plus chemotherapy and immunotherapy for advanced intrahepatic cholangiocarcinoma

  This trial will test whether adding the oral drug chidamide to gemcitabine/cisplatin and an immune checkpoint inhibitor helps people with unresectable or metastatic intrahepatic cholangiocarcinoma who have not had prior systemic therapy.

  Recruiting Phase 2 Shanghai Zhongshan Hospital · Shanghai, Shanghai Municipality · NCT07570849

• VG2025 in intrahepatic cholangiocarcinoma

  VG2025 is tested in adults with advanced intrahepatic cholangiocarcinoma to see if it can help control tumors and be safe.

  Recruiting Phase 2 Virogin Biotech Ltd. · Hangzhou, Zhejiang · NCT07522476

• MRI-guided adaptive single-session radiation for liver tumors (SABR)

  This trial will test a single-session, MRI-guided adaptive high-dose radiation (SABR) for adults with primary or metastatic liver tumors to see if on-table MRI planning and replanning can treat tumors without a separate simulation visit.

  Recruiting Phase 2 Stanford University · Palo Alto, California · NCT07223307

• Hybrid hospital and community delivery of hepatic artery infusion chemotherapy for liver metastases and intrahepatic cholangiocarcinoma

  This Phase 2 trial will test whether giving floxuridine through a surgically implanted hepatic artery infusion pump — with follow-up care either at a major hospital or by local community oncologists — is safe and practical for adults with colorectal cancer liver metastases or unresectable intrahepatic cholangiocarcinom

  Recruiting Phase 2 University of Kentucky · Lexington, Kentucky · NCT07201519

• ALE.P03 alone for adults with advanced CLDN1-positive solid tumors

  This trial tests whether ALE.P03 given alone is safe and can shrink tumors in adults with advanced CLDN1-positive cancers who have already tried standard treatments.

  Recruiting at 41 sites Phase 1/2 Alentis Therapeutics AG · Phoenix, Arizona and 40 other locations · NCT07169734

• Outpatient versus inpatient care for catheter-based treatment of primary liver cancer (CHOC)

  This trial will see if having TACE or TARE as an outpatient (ambulatory) procedure is as safe and more satisfying than staying in the hospital for adults with hepatocellular carcinoma or intrahepatic cholangiocarcinoma.

  Recruiting at 16 sites University Hospital, Angers · Amiens and 18 other locations · NCT06990659

• Liver transplant after SIRT and chemotherapy for locally advanced intrahepatic cholangiocarcinoma

  This trial tries to see if SIRT and chemotherapy followed by a liver transplant helps people with unresectable, non-metastatic intrahepatic cholangiocarcinoma live longer.

  Recruiting Assistance Publique - Hôpitaux de Paris · Clichy-sous-Bois · NCT06910722

• Direct chemotherapy delivery to the liver for bile duct cancer patients

  This study is testing if delivering chemotherapy directly to the liver can help adults with bile duct cancer live longer and feel better after surgery.

  Recruiting Phase 2 Erasmus Medical Center · Rotterdam, South Holland · NCT06888063

• Pemigatinib plus durvalumab for previously treated advanced intrahepatic cholangiocarcinoma with FGFR2 fusion

  This will test whether combining the FGFR inhibitor pemigatinib with the immunotherapy durvalumab helps adults with advanced intrahepatic cholangiocarcinoma that has an FGFR2 fusion and who have already received prior treatment.

  Recruiting at 3 sites Phase 2 Hoosier Cancer Research Network · Birmingham, Alabama and 2 other locations · NCT06728410

• Treatment for high-risk recurrent intrahepatic cholangiocarcinoma using Tislelizumab and S-1

  This study is testing if a combination of the immunotherapy drug Tislelizumab and the chemotherapy drug S-1 can help people with high-risk recurrent intrahepatic cholangiocarcinoma feel better after surgery.

  Recruiting at 2 sites Phase 2 Anhui Provincial Hospital · Fuyang, Anhui and 1 other locations · NCT06664021

• Combining D-TACE-HAIC with Envafolimab and Lenvatinib for treating advanced liver cancer

  This study is testing a new treatment combining D-TACE-HAIC, Envafolimab, and Lenvatinib to see if it helps people with advanced liver cancer that can't be surgically removed.

  Recruiting Fujian Provincial Hospital · Fuzhou, Fujian · NCT06643208

• Evaluating HNF4α srRNA for treating advanced intrahepatic cholangiocarcinoma

  This study is testing a new treatment called HNF4α srRNA to see if it is safe and effective for people with advanced intrahepatic cholangiocarcinoma.

  Recruiting Early Phase 1 Shanghai Changzheng Hospital · Shanghai, Shanghai Municipality · NCT06583993

• Neoantigen Vaccine combined with Capecitabine for treating intrahepatic cholangiocarcinoma after surgery

  This study is testing if a new vaccine combined with a cancer drug can help patients with a specific type of liver cancer after surgery to reduce the chance of it coming back.

  Recruiting Early Phase 1 Meng Chao Hepatobiliary Hospital of Fujian Medical University · Fuzhou, Fujian · NCT06406816

• Combining radioembolization and biological therapy for advanced bile duct cancer

  This study is testing a new treatment for advanced bile duct cancer that combines a special type of radiation therapy with immune and chemotherapy drugs to see if it can work better for patients whose tumors can't be removed.

  Recruiting at 4 sites Phase 2 IRCCS San Raffaele · Bergamo and 3 other locations · NCT06375915

• Liquid biopsy to differentiate types of primary liver cancer

  This study is testing a new blood test to see if it can tell the difference between two types of liver cancer, hepatocellular carcinoma and intrahepatic cholangiocarcinoma, to help doctors diagnose patients more safely.

  Recruiting at 5 sites City of Hope Medical Center · Duarte, California and 4 other locations · NCT06342414

• Combining liver-directed therapy (HAI pump or SIRT) with GemOx chemotherapy for unresectable intrahepatic cholangiocarcinoma (TOMCAT)

  This trial will test whether adding a liver-directed treatment (either a hepatic artery infusion pump delivering floxuridine or selective internal radiation therapy) to GemOx chemotherapy helps shrink or control intrahepatic cholangiocarcinoma that cannot be removed by surgery.

  Recruiting Phase 2 Oslo University Hospital · Oslo, Oslo · NCT06313203

• Combined therapy for advanced intrahepatic cholangiocarcinoma

  This study is testing a new combination of chemotherapy and targeted therapy to see if it can help people with advanced bile duct cancer feel better and live longer.

  Recruiting Phase 2 Nanfang Hospital, Southern Medical University · Guangzhou, Guangdong · NCT06298968

• Treatment for resectable intrahepatic cholangiocarcinoma using a combination of drugs and chemotherapy

  This study is testing a new combination of drugs and chemotherapy to see if it can help people with resectable intrahepatic cholangiocarcinoma live longer and prevent the cancer from coming back after surgery.

  Recruiting Phase 2 Shandong Cancer Hospital and Institute · Jinan, Shandong · NCT06296563

• Neoadjuvant therapy for resectable intrahepatic cholangiocarcinoma

  This study is testing a new combination of chemotherapy and targeted therapy to see if it helps people with a specific type of liver cancer avoid recurrence after surgery.

  Recruiting at 3 sites Phase 2 The First Affiliated Hospital with Nanjing Medical University · Nanjing, Jiangsu and 2 other locations · NCT06208462

• Liver transplantation for patients with advanced intrahepatic cholangiocarcinoma

  This study is testing if liver transplantation can help patients with advanced bile duct cancer live longer after they’ve had treatment, compared to those who only received chemotherapy.

  Recruiting at 2 sites Rutgers, The State University of New Jersey · Newark, New Jersey and 1 other locations · NCT06140134

• Combining local therapy with ongoing systemic treatment for certain cancers

  This study is testing whether adding local treatments to ongoing systemic therapy can help people with certain cancers keep their disease under control for longer.

  Recruiting University of California, Davis · Sacramento, California · NCT06101277

• Liver transplantation for patients with advanced intrahepatic cholangiocarcinoma

  This study is testing whether liver transplantation can help people with advanced bile duct cancer who can't have surgery feel better and live longer after receiving chemotherapy first.

  Recruiting Azienda Sanitaria Ospedaliera · Padova · NCT06098547

• Neoadjuvant therapy for high-risk intrahepatic cholangiocarcinoma patients

  This study is testing a new combination treatment for patients with high-risk intrahepatic cholangiocarcinoma to see if it can improve their chances of successful surgery and survival.

  Recruiting Phase 2 Zhejiang Cancer Hospital · Hangzhou, Zhejiang and 1 other locations · NCT05557578

• Combining chemotherapy and Yttrium-90 treatment for liver cancer

  This study is testing a new combination of chemotherapy and Yttrium-90 treatment to see if it can help people with liver cancer shrink their tumors and manage their disease better than standard treatments.

  Recruiting Phase 2 Inova Health Care Services · Fairfax, Virginia · NCT05422690

• Combination treatment for advanced intrahepatic cholangiocarcinoma

  This study is testing if a new combination of medications can help people with advanced liver cancer live longer and feel better compared to standard chemotherapy.

  Recruiting Phase 3 Shanghai Junshi Bioscience Co., Ltd. · Shanghai, Shanghai Municipality · NCT05342194

• Aerosolized chemotherapy for biliary tract cancer with peritoneal metastases

  This study is testing a new way to deliver chemotherapy directly into the abdomen for patients with biliary tract cancer that has spread to see if it helps them live longer and feel better.

  Recruiting Phase 1 City of Hope Medical Center · Duarte, California · NCT05285358

• Combining Lenvatinib and Sintilimab for Advanced Liver Cancer After Previous Treatment

  This study is testing if combining two medications, Lenvatinib and Sintilimab, can help people with advanced liver cancer who have already tried other treatments.

  Recruiting Phase 2 Fudan University · Shanghai, Shanghai Municipality · NCT05010681

• Combining TACE with Tislelizumab for advanced intrahepatic cholangiocarcinoma

  This study is testing if combining a liver cancer treatment called TACE with a new immune therapy called Tislelizumab can help people with advanced intrahepatic cholangiocarcinoma who haven't responded to previous treatments.

  Recruiting Phase 2 Fudan University · Shanghai, Shanghai Municipality · NCT04954781

• Chemotherapy with or without a pump for inoperable cholangiocarcinoma

  This study is testing if adding a special pump treatment to standard chemotherapy can help people with inoperable cholangiocarcinoma live longer without their cancer getting worse.

  Recruiting at 8 sites Phase 2 Memorial Sloan Kettering Cancer Center · Bethesda, Maryland and 10 other locations · NCT04891289

• Liver transplantation for patients with non-resectable bile duct cancer

  This study is testing if liver transplantation can help people with inoperable bile duct cancer live longer and feel better.

  Recruiting Oslo University Hospital · Oslo · NCT04556214

• Combining cryoablation with anti-PD-1 therapy for advanced intrahepatic cholangiocarcinoma

  This study is testing if combining a freezing treatment with an immune therapy can help people with advanced bile duct cancer who haven't responded to earlier treatments.

  Recruiting Phase 2 Fudan University · Shanghai · NCT04299581

• Surgery for Intrahepatic Cholangiocarcinoma with Lymph Node Dissection

  This study is testing if a more extensive lymph node removal during surgery for liver cancer can help patients live longer and have better outcomes compared to standard surgery.

  Recruiting at 13 sites Second Affiliated Hospital, Zhejiang University, School of Medicine · Baltimore, Maryland and 12 other locations · NCT04078230

NIH-funded research (11)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• A new mouse model to study intrahepatic cholangiocarcinoma and its immunotherapy

  A new mouse model helps researchers understand intrahepatic cholangiocarcinoma and test immune-based treatments to improve outcomes.

  NIH research Sanford Burnham Prebys Medical Discovery Institute · La Jolla, United States · NIH-11413830

• Radiation plus a patient’s own immune cells to boost cholangiocarcinoma treatment

  This project tests a therapy that combines precise radiation and the patient’s own dendritic cells with immune drugs to help fight intrahepatic cholangiocarcinoma in people who cannot have surgery.

  NIH research Mayo Clinic Rochester · Rochester, United States · NIH-11408644

• New mouse model to improve immune therapy for intrahepatic bile duct (cholangiocarcinoma) cancer

  This project builds a new mouse model to help make immune-based treatments work better for people with intrahepatic cholangiocarcinoma, a type of bile duct liver cancer.

  NIH research Sanford Burnham Prebys Medical Discovery Institute · La Jolla, United States · NIH-11392619

• Understanding how tumor variety affects bile duct cancer (iCCA)

  Researchers will study how differences within a single tumor and between primary and metastatic sites influence disease progression and treatment response in intrahepatic cholangiocarcinoma, using human samples and mouse models.

  NIH research University of Tx Md Anderson Can Ctr · Houston, United States · NIH-11281627

• Using radiation and your own immune cells to boost immunotherapy for intrahepatic bile-duct (liver) cancer

  This approach combines focused liver radiation, injections of your own dendritic immune cells, and two immune drugs to try to help people with unresectable intrahepatic bile-duct cancer live longer without the disease getting worse.

  NIH research Mayo Clinic Rochester · Rochester, United States · NIH-11142663

• Noninvasive methods to identify mutations in liver cancer

  This study is looking for better ways to diagnose a type of liver cancer called intrahepatic cholangiocarcinoma (iCCA) by using noninvasive methods to check for important genetic changes, which can help doctors choose the best treatment for patients.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11092682

• Finding new treatments for bile duct cancer

  This study is looking at bile duct cancer to find specific markers in the genes and proteins that could help create better treatments for patients, making it easier to fight this tough disease.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11053521

• Investigating new treatment pathways for a deadly liver cancer

  This study is looking at a type of liver cancer called intrahepatic cholangiocarcinoma and is testing a new approach to treatment that uses a drug called dasatinib for patients whose tumors have certain genetic changes, hoping to find better options than standard chemotherapy.

  NIH research Fred Hutchinson Cancer Center · Seattle, United States · NIH-11044148

• Combining radiation and immune cells to enhance treatment for liver cancer

  This study is testing a new way to help people with a tough type of liver cancer by using strong radiation along with special immune cells from their own body to boost their immune system and help them live longer without the cancer getting worse.

  NIH research Mayo Clinic Rochester · Rochester, United States · NIH-10998056

• A new mouse model to study liver cancer and improve its treatment

  This study is looking at a tough type of liver cancer called intrahepatic cholangiocarcinoma and is testing a new mouse model to learn more about how the immune system interacts with this cancer, hoping to find better treatment options that work alongside current therapies.

  NIH research University of California, San Diego · La Jolla, United States · NIH-10931375

• Improving treatment outcomes for patients with advanced bile duct cancer.

  This study is looking at a new way to treat patients with advanced bile duct cancer by comparing a standard chemotherapy with an added treatment delivered directly to the liver, to see which helps people live longer.

  NIH research Sloan-Kettering Inst Can Research · New York, United States · NIH-10897008

Related topics

Quick answers

How many Intrahepatic Cholangiocarcinoma clinical trials are recruiting right now?

35, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 11 countries. The most sites are in China (17 trials), United States (12 trials), France (3 trials), Italy (3 trials), Netherlands (3 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 20, Early Phase 1: 2, Phase 1/2: 2, Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

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