Combining radiation and immune cells to enhance treatment for liver cancer
Radiation and dendritic cell combination to improve immunotherapy response in intrahepatic cholangiocarcinoma
This study is testing a new way to help people with a tough type of liver cancer by using strong radiation along with special immune cells from their own body to boost their immune system and help them live longer without the cancer getting worse.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project ID | NIH-10998056 on NIH RePORTER |
What this research studies
This research investigates a new treatment approach for intrahepatic cholangiocarcinoma (iCCA), a challenging form of liver cancer. It combines high-dose radiation therapy with injections of the patient's own immune cells, known as dendritic cells, to improve the effectiveness of existing immunotherapy. By using radiation to stimulate the immune response and then enhancing it with dendritic cells, the goal is to increase the body's ability to fight the cancer. This innovative method aims to extend the time patients can live without disease progression.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with unresectable intrahepatic cholangiocarcinoma who have not responded adequately to standard treatments.
Not a fit: Patients with resectable iCCA or those who have already undergone extensive treatment may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could significantly improve survival rates and quality of life for patients with unresectable iCCA.
How similar studies have performed: Previous pilot studies using similar approaches have shown promising results, indicating potential for success in this novel treatment strategy.
Where this research is happening
Rochester, United States
- Mayo Clinic Rochester — Rochester, United States (Active)
Researchers
- Principal investigator: Park, Sean S — Mayo Clinic Rochester
- Study coordinator: Park, Sean S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.