Noninvasive methods to identify mutations in liver cancer
Noninvasive assessment of IDH mutation status in intrahepatic cholangiocarcinoma
This study is looking for better ways to diagnose a type of liver cancer called intrahepatic cholangiocarcinoma (iCCA) by using noninvasive methods to check for important genetic changes, which can help doctors choose the best treatment for patients.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-11092682 on NIH RePORTER |
What this research studies
This research focuses on improving the diagnosis of intrahepatic cholangiocarcinoma (iCCA), a type of liver cancer with a poor prognosis. It aims to develop noninvasive techniques to assess the presence of specific mutations, particularly the IDH mutation, which is crucial for tailoring treatment options. By analyzing biological markers related to this mutation, the research seeks to enhance diagnostic accuracy and facilitate timely treatment for patients. The study will utilize advanced imaging techniques and molecular analysis to achieve these goals.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with intrahepatic cholangiocarcinoma or those at high risk for this type of liver cancer.
Not a fit: Patients with other types of liver cancer or those without a diagnosis of cholangiocarcinoma may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more accurate and timely diagnoses of iCCA, improving treatment outcomes for patients.
How similar studies have performed: Previous research has shown promise in using noninvasive methods for diagnosing cancer, indicating potential success for this approach.
Where this research is happening
Philadelphia, United States
- University of Pennsylvania — Philadelphia, United States (Active)
Researchers
- Principal investigator: Zavriyev, Alexander — University of Pennsylvania
- Study coordinator: Zavriyev, Alexander
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.