Condition

Extrahepatic Cholangiocarcinoma clinical trials and research

• 7Clinical trials
• 1New in 30 days
• 6Countries

Newest Extrahepatic Cholangiocarcinoma clinical trials

All recruiting trials (7)

• PDT plus radioactive biliary stent for unresectable extrahepatic cholangiocarcinoma

  This study tests whether combining photodynamic therapy with a self-expandable radioactive stent can help patients with unresectable extrahepatic cholangiocarcinoma stay cancer-free longer and keep their bile ducts open.

  Recruiting The First Affiliated Hospital of Zhengzhou University · Zhengzhou, Henan · NCT07916870

• Dual-target HER2/CEA CAR-NK Cells in Advanced Biliary Tract Cancer

  This trial tests a ready-to-use CAR-NK cell therapy that targets HER2 and CEACAM5 in adults with unresectable or metastatic biliary tract cancers after standard therapy to see if it can help control the disease.

  Recruiting Phase 1/2 Beijing Biotech · Shenzhen, Guangdong · NCT07641036

• Repeated endobiliary radiofrequency ablation with durvalumab, gemcitabine, and cisplatin for unresectable extrahepatic bile duct cancer

  This trial tests whether adding repeated endobiliary radiofrequency ablation to standard durvalumab plus gemcitabine and cisplatin helps people with unresectable extrahepatic bile duct cancer live longer.

  Recruiting at 8 sites Aichi Medical University · Aichi and 7 other locations · NCT07235007

• Blood test using cfDNA methylation to screen for biliary tract cancers

  This study tests whether a blood test that reads cfDNA methylation can detect biliary tract cancers early in adults with or suspected of having these cancers.

  Recruiting Shanghai Jiao Tong University School of Medicine · Shanghai, Shanghai Municipality · NCT07176962

• Neoadjuvant gemcitabine and cisplatin with perioperative pembrolizumab vs upfront surgery for cancers of the bile ducts

  This trial tests whether giving chemotherapy with pembrolizumab before surgery helps people with resectable or borderline resectable extrahepatic cholangiocarcinoma see if they have better outcomes than going straight to surgery.

  Recruiting Phase 2/3 Amsterdam UMC, location VUmc · Amsterdam · NCT06923475

• Combining Durvalumab with Radiofrequency Ablation for Treating Extrahepatic Cholangiocarcinoma

  This study is testing if combining a new immunotherapy with radiofrequency ablation and chemotherapy can help people with a type of bile duct cancer that can't be surgically removed.

  Recruiting at 12 sites Phase 2 Institut für Klinische Krebsforschung IKF GmbH at Krankenhaus Nordwest · Aachen and 11 other locations · NCT06440993

• Combining local therapy with ongoing systemic treatment for certain cancers

  This study is testing whether adding local treatments to ongoing systemic therapy can help people with certain cancers keep their disease under control for longer.

  Recruiting University of California, Davis · Sacramento, California · NCT06101277

Related topics

Quick answers

How many Extrahepatic Cholangiocarcinoma clinical trials are recruiting right now?

7, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 6 countries. The most sites are in China (3 trials), Netherlands (1 trial), Japan (1 trial), South Korea (1 trial), Germany (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2/3: 1, Phase 2: 1, Phase 1/2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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