Condition

IBS (Irritable Bowel Syndrome) clinical trials and research

• 15Clinical trials
• 2New in 30 days
• 9Countries

Newest IBS (Irritable Bowel Syndrome) clinical trials

All recruiting trials (15)

• IBS and rosacea in adults: how common is rosacea among people with IBS at a university center

  This observational study tests how often rosacea occurs in adults with IBS who are treated at a university hospital in Bologna.

  Recruiting IRCCS Azienda Ospedaliero-Universitaria di Bologna · Bologna, Italy · NCT07922668

• Probiotic in IBS-D and functional diarrhea (three-month test)

  A probiotic capsule is being tested to see if it can improve symptoms and quality of life for adults with diarrhea-predominant IBS or functional diarrhea compared with a placebo.

  Recruiting Szeged University · Szeged · NCT07916688

• UCB8600 and mast cell activation in the gut for IBS

  This study tests whether UCB8600 can reduce mast cell activation in the gut to help people with IBS.

  Recruiting KU Leuven · Leuven, Vlaams-Brabant · NCT07655375

• Regular enzyme blend to help bloating in adults with IBS and similar symptoms

  This study tests whether a FODMAP-targeting digestive enzyme blend (taken with meals) reduces bloating and related gut symptoms compared with placebo in adults who self-report bloating.

  Recruiting Kiwi Health Inc · Los Angeles, California · NCT07591584

• Wheat sensitivity or IBS/functional dyspepsia in relatives of people with celiac disease

  This project will test whether adults related to celiac patients have higher rates of non-celiac wheat sensitivity or IBS/functional dyspepsia and whether symptoms change on a wheat-free diet.

  Recruiting at 2 sites University of Palermo · Palermo, PA and 1 other locations · NCT07584473

• Variable Compression System for moderate to severe IBS

  This pilot will try a wearable Variable Compression System device for adults with moderate to severe IBS to see if wearing it reduces symptoms and is safe.

  Recruiting at 3 sites PGP Health · Kissimmee, Florida and 2 other locations · NCT07540312

• Gut microbiome in post-infectious irritable bowel syndrome

  This project will test whether adults with post‑infectious IBS have different gut microbiome patterns compared with people who recovered from an infection and healthy adults.

  Recruiting Fondazione Policlinico Universitario Agostino Gemelli IRCCS · Rome · NCT07517029

• Sucrase‑isomaltase genes and meal response in people with IBS

  This research will test whether people with IBS who have reduced sucrase‑isomaltase enzyme activity have a smaller rise in blood sugar and more bowel symptoms after a sugar‑rich meal than people with normal enzyme activity.

  Recruiting Region Skane · Malmö, Skåne County · NCT07309601

• Saccharomyces boulardii probiotic for non-constipated IBS (diarrhea or mixed)

  This trial will test whether the probiotic Saccharomyces boulardii CNCM I-745 reduces overall symptoms in adults (18–65) with non-constipated IBS compared with placebo after 8 weeks.

  Recruiting at 3 sites Phase 3 Biocodex · Braga and 9 other locations · NCT07168434

• Low-frequency rTMS to reduce belly pain in diarrhea-predominant IBS

  This trial tests whether low-frequency repetitive transcranial magnetic stimulation (rTMS) to a brain region can reduce visceral (belly) pain in adults with IBS-D.

  Recruiting The First Affiliated Hospital of Soochow University · Suzhou, Jiangsu · NCT06757491

• Rifaximin plus N-acetylcysteine (NAC) for diarrhea-predominant IBS

  This study will see if adding the supplement N-acetylcysteine (NAC) to rifaximin helps adults with IBS-D have less belly pain and firmer stools.

  Recruiting Phase 2 Cedars-Sinai Medical Center · Los Angeles, California · NCT06727422

• Combining a low-FODMAP diet with mirtazapine to treat IBS with diarrhea

  This study is testing if combining a low-FODMAP diet with the medication mirtazapine can help adults with diarrhea-predominant irritable bowel syndrome feel better and improve their quality of life.

  Recruiting Early Phase 1 Mayo Clinic · Jacksonville, Florida · NCT06684470

• Sampling gut bacteria in patients with IBS and functional gastrointestinal disorders

  This study is trying to collect gut bacteria samples from people with Irritable Bowel Syndrome and other digestive issues to see how their microbiome differs from healthy individuals.

  Recruiting Stanford University · Redwood City, California · NCT06215222

• Using probiotics to treat Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

  This study is testing if a new probiotic can help people aged 45 to 70 with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and possibly irritable bowel syndrome feel better.

  Recruiting Phase 2 Nova Southeastern University · Fort Lauderdale, Florida · NCT06211062

• Using ethosuximide and pentoxifylline to treat abdominal pain from IBS

  This study is testing if the medications ethosuximide and pentoxifylline can help adults with irritable bowel syndrome feel less abdominal pain.

  Recruiting Phase 3 Tanta University · Tanta · NCT04217733

Related topics

Quick answers

How many IBS (Irritable Bowel Syndrome) clinical trials are recruiting right now?

15, as of November 12, 2026. 2 of them were first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 9 countries. The most sites are in United States (6 trials), Italy (3 trials), Hungary (1 trial), Egypt (1 trial), China (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 2, Phase 3: 2, Early Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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