Sucrase‑isomaltase genes and meal response in people with IBS

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Participants previously genotyped for sucrase‑isomaltase and other carbohydrate‑processing genes are invited for a single fasting visit. After completing symptom questionnaires, each person eats a standardized sugar‑rich meal and blood is drawn before the meal and at multiple time points up to 120 minutes to measure glucose. At the same time points they report bowel symptoms, and the team compares glucose responses and symptom changes between those with reduced enzyme activity and those with normal activity. The study will also examine correlations between blood glucose levels and symptom severity.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Diagnosis of irritable bowel syndrome (IBS)
* Gene testing has been conducted regarding genes regulating the production of sucrase-isomaltase ensymes in previous dietary interventions using the starch- and sucrose reduced diet (SSRD) or multi-center study.

Exclusion Criteria:

* Diagnosis of inflammatory bowel disease, celiac disease, bile salt malabsorption, gastroenteritis or enteric dysmotility
* Severe food allergy
* Serious heart-, lung-, cardiovascular-, malignant- or mental illness
* Ongoing eating disorder
* Pregnancy
* Recent major gastrointestinal surgery
* Alcohol and/or drug addiction

Where it's running

• Skåne University Hospital
  Malmö, Skåne County, Sweden Recruiting

Study contacts

• Study coordinator: Bodil Ohlsson C Professor, MD, PhD
• Email: bodil.ohlsson@med.lu.se
• Phone: +46+402712660

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.