Using ethosuximide and pentoxifylline to treat abdominal pain from IBS

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial investigates the effectiveness of ethosuximide and pentoxifylline in alleviating abdominal pain associated with irritable bowel syndrome (IBS). Participants will be adults aged 18 and older who meet specific IBS criteria and have experienced significant pain in the week prior to enrollment. The study aims to determine if these medications can enhance current treatment options for IBS-related pain. The trial will involve a controlled intervention to assess pain relief and overall patient outcomes.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* • Age ≥ 18 years,

  * Man and Women, Negative pregnancy test and effective contraception,
  * IBS defined by the Rome criteria IV
  * During the previous seven days the inclusion visit, average numeric rating scale (NRS) pain ≥ 4.
  * IBS Treatment stable for 1 month

Exclusion Criteria:

* • Breastfeeding

  * Diabetic patients
  * Significant liver function abnormalities (transaminases\> 3N, cholestasis) and moderate renal disease (MDRD \<60 ml / min)
  * Addiction to alcohol and / or drugs,
  * Antiepileptic drugs taken (epilepsy or chronic pain)
  * Chronic pain of greater intensity than that related to IBS,
  * Known Allergyto succinimides (ethosuximide, methsuximide, phensuximide) and pentoxifylline.
  * History or current severe depression (hospitalization, long-term antidepressant treatment)
  * Psychotic disorders,

Where it's running

• Sherief Abd-Elsalam
  Tanta, Egypt Recruiting

Study contacts

• Principal investigator: Mostafa Mahmoud Bahaa El dien, Msc — Clinical Pharmacy department
• Study coordinator: Sherief Abd-Elsalam, ass. prof.
• Email: sheriefabdelsalam@yahoo.com
• Phone: 00201147773440

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.