Low-frequency rTMS to reduce belly pain in diarrhea-predominant IBS

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

In a randomized, sham-controlled, double-blind design, 42 adults with diarrhea-predominant IBS were assigned 1:1 to active low-frequency rTMS or sham over the medial prefrontal cortex for a two-week intervention. A nested cohort of 21 participants underwent baseline functional MRI to identify central pain hubs and to explore neural mechanisms of analgesia. Allocation was concealed with opaque envelopes and both participants and outcome assessors were blinded; rTMS operators were separated from outcome assessment. Outcomes combined clinical pain measures and fMRI analyses to link symptom change with brain activity.

Why it matters

Who can join: the full rules

All diagnoses were made by board-certified gastroenterologists. Eligible participants met the following inclusion criteria: (1) age between 18 and 75 years; (2) fulfillment of the Rome IV diagnostic criteria for IBS-D. Exclusion criteria included: (1) presence of inflammatory or other organic gastrointestinal diseases; (2) diagnosed psychiatric disorders; (3) history of anorectal, intestinal, or abdominal surgery; (4) pregnancy or lactation; (5) presence of metallic implants or cardiac pacemakers.

Where it's running

• The First Affiliated Hospital of Soochow University
  Suzhou, Jiangsu, China Recruiting

Study contacts

• Principal investigator: Rui Li, Dr. — The First Affiliated Hospital of Soochow University
• Study coordinator: Ruixia Weng, Dr.
• Email: wengruixia@suda.edu.cn
• Phone: 15206214921

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.