Probiotic in IBS-D and functional diarrhea (three-month test)

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Adults with IBS-D or functional diarrhea will take a daily probiotic capsule for 3 months and then switch to a placebo for another 3 months, or vice versa, in a randomized, blinded design. Participants will complete quality-of-life questionnaires and track bowel habits to see if the probiotic helps normalize stool and reduce bowel movements. The study also aims to assess safety and tolerability of the probiotic. Rome V criteria are used to confirm eligibility, and prior stable treatment for IBS-D/FD is required.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adults aged 18 years or older.
* Have diarrhea-predominant irritable bowel syndrome (IBS-D) or functional diarrhea (FD) diagnosed using Rome V criteria.
* Have had symptoms for at least 6 months.
* Have no warning signs that suggest another digestive disease.
* Have been taking the same treatment for IBS-D, FD, and other medical conditions for at least 1 month before joining the study.
* Are willing and able to provide written informed consent and follow study procedures.

Exclusion Criteria:

* Took antibiotics or probiotic products within the past 4 weeks.
* Had abdominal surgery in the past, except appendix removal (appendectomy).
* Have another type of irritable bowel syndrome or another functional digestive disorder.
* Have a known digestive disease that may explain their symptoms.
* Plan to start a new medication or change the dose of an existing medication during the study (except antispasmodic medications).
* Are unable or unwilling to complete study questionnaires and daily symptom records.

Where it's running

• University of Szeged
  Szeged, Hungary Recruiting

Study contacts

• Study coordinator: Tamás Molnár
• Email: molnar.tamas@med.u-szeged.hu
• Phone: +36-62-545-189

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.