Investigating heart function improvement in patients with specific heart pacing methods
Official title: Investigation of Whether the Presence of the Typical LBBB- Mechanical Stimulation Pattern - Documented Through 2DSE (Two-dimensional Strain Echocardiography) - is Associated With Increased Rates of Acute Improvement in Global Myocardial Work Efficiency (GWE) Compared to the Absence of This Activation Pattern, in Patients in Need of Device Implantation for Cardiac Resynchronization Therapy in Whom LBBp is Chosen Compared to the Classic Biventricular Pacing Method
Run by University Hospital of Patras · NCT06689111 · Data updated 2026-11-12
This study tests whether a new heart pacing method can help people with heart failure feel better compared to the standard pacing method.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 90 Years |
| Sex | All |
| Enrollment | 100 (estimated) |
| Sponsor | University Hospital of Patras Academic / other |
| Locations | 1 site (Pátrai, Greece) |
| Status | Recruiting |
| Started | May 23, 2024 |
| Main results expected | September 30, 2026 |
| Study ends | November 30, 2026 |
| Registry record updated | December 5, 2025 |
| Trial ID | NCT06689111 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults aged 18 to 90 with symptomatic heart failure and a documented indication for resynchronization therapy.
✕Probably not a fit
Patients with right bundle branch block or atypical LBBB QRS morphology may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This multicenter interventional study aims to assess the relationship between a specific echocardiographic contraction pattern and the acute improvement in myocardial function in patients receiving cardiac resynchronization therapy. It focuses on patients with heart failure and reduced ejection fraction who require an implantable device. The study compares outcomes between those receiving left bundle branch pacing and conventional biventricular pacing, utilizing advanced echocardiographic techniques to evaluate heart function. The goal is to identify which patients are most likely to benefit from these therapies based on their echocardiographic patterns.
Why it matters
Potential benefit: If successful, this study could lead to improved patient selection for cardiac resynchronization therapy, enhancing treatment outcomes for heart failure patients.
How similar studies have gone: Other studies have shown promising results using echocardiographic patterns to predict responses to cardiac resynchronization therapy, indicating this approach has potential.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * \>18 years \< 90 years * Patients with a documented indication for resynchronization therapy \[symptomatic patients despite optimal medication, HFrEF (EF\<35%), LBBB QRS morphology\] * COMPLETE LBBB (LBBB defined as QRS\>130msec, wide "notched or slurred" R wave in leads I, aVL, V5, V6 and occasional RS pattern in V5, V6, absence of Q waves in leads I, V5 and V6 but in lead aVL narrow Q wave may be present in the absence of myocardial pathology, R peak time \>60ms in leads V5 and V6 but normal in leads V1, V2, V3 when small R's are discernible in precardial leads, ST and T usually opposite to QRS direction) * Patients with ntraventricular septum diameter \>8 mm * Written informed consent Exclusion Criteria: * Patients with RBBB or atypical LBBB QRS morphology * Patients eligible for an upgrade procedure (already carring a PM or ICD) * Patients with hypertrophic cardiomyopathy
Where it's running
-
University Hospital of Patras
Pátrai, Greece, Greece Recruiting
Study contacts
- Study coordinator: Georgios Leventopoulos, MD, PhD
- Email: levent2669@hotmail.com
- Phone: 30 2613603281
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.