Condition

Head and Neck Squamous Cell Carcinoma (HNSCC) clinical trials and research

• 23Clinical trials
• 21Countries

Newest Head and Neck Squamous Cell Carcinoma (HNSCC) clinical trials

All recruiting trials (23)

• Triple-drug neoadjuvant therapy for EGFR-positive locally advanced head and neck cancer

  This trial tests a three-drug neoadjuvant regimen (Becotatug Vedotin, Pucotenlimab, and Cisplatin) in adults with EGFR-positive, locally advanced head and neck cancer to see if it can shrink tumors before surgery or chemoradiotherapy.

  Recruiting at 2 sites Phase 2 Sun Yat-sen University · Guangzhou, Guangdong and 1 other locations · NCT07814287

• CCR2 PET Imaging for Head and Neck Squamous Cell Carcinoma

  This trial tests whether Cu-64 DOTA-ECL1i PET/CT can reliably detect HNSCC in adults, including those with new locally advanced disease or suspected/confirmed recurrent/metastatic cancer.

  Recruiting Phase 2 Washington University School of Medicine · St Louis, Missouri · NCT07659678

• Nimotuzumab plus Immunotherapy and Chemotherapy before surgery for locally advanced head and neck cancer

  This phase 2 trial tests whether adding nimotuzumab to immunotherapy and chemotherapy before surgery helps people with locally advanced head and neck squamous cell carcinoma.

  Recruiting Phase 2 Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine · Shanghai · NCT07601737

• Re-irradiation with chidamide for recurrent head and neck squamous cell carcinoma

  This trial will test whether adding the drug chidamide to repeat radiation is safe and tolerable for adults whose head and neck squamous cell carcinoma has returned after prior radiotherapy.

  Recruiting Phase 1 West China Hospital · Chengdu, Sichuan · NCT07545967

• Dose-finding of EXS74539 (REC-4539) in select solid tumors

  This study will try different doses of the experimental drug EXS74539 in adults with select solid tumors to find a safe and tolerable dose.

  Recruiting at 3 sites Phase 1 Exscientia AI Limited · Los Angeles, California and 2 other locations · NCT07517198

• Ficerafusp alfa plus pembrolizumab before surgery for resectable head and neck squamous cell carcinoma

  This trial will test whether giving ficerafusp alfa together with pembrolizumab before surgery helps people with PD‑L1–positive, resectable, high‑risk head and neck squamous cell carcinoma.

  Recruiting at 2 sites Phase 2 Dana-Farber Cancer Institute · Boston, Massachusetts and 1 other locations · NCT07465276

• EPI-326 for EGFR-mutant non-small cell lung cancer and head and neck squamous cell carcinoma

  This phase 1 trial will try EPI-326, a new drug, in people with EGFR-mutant non‑small cell lung cancer or advanced head and neck squamous cell carcinoma to find safe doses, study how the body handles it, and look for early signs it shrinks tumors.

  Recruiting at 8 sites Phase 1 EpiBiologics · Los Angeles, California and 7 other locations · NCT07462377

• GV20-0251 with sintilimab given before surgery for resectable head and neck cancer

  This treatment combination will be given before surgery to test safety and early anti-tumor activity in adults with resectable, locally advanced head and neck squamous cell carcinoma.

  Recruiting Phase 1 West China Hospital · Chengdu · NCT07457281

• STRO-004 treatment in adults with recurrent or metastatic solid tumors

  This study will test whether STRO-004, alone and with pembrolizumab, is safe and can shrink tumors in adults with several types of metastatic cancers that often express Tissue Factor.

  Recruiting at 9 sites Phase 1 Sutro Biopharma, Inc. · San Diego, California and 8 other locations · NCT07227168

• Patient-reported symptom monitoring for people with head and neck cancer

  This trial will test whether remote digital symptom monitoring during and after radiotherapy helps reduce significant weight loss in adults treated for localized head and neck squamous cell carcinoma.

  Recruiting Centre Henri Becquerel · Rouen and 1 other locations · NCT07190755

• AK129 combination therapy for advanced solid tumors

  This study tests AK129 given with chemotherapy in adults with advanced non-small cell lung, head and neck, or colorectal cancers to find a safe dose and see if it helps control their disease.

  Recruiting Phase 1/2 Akeso · Shenyang, Liaoning · NCT06943820

• Evaluating MT-4561 in Patients with Advanced Solid Tumors

  This study is testing a new drug called MT-4561 to see if it is safe and effective for people with advanced solid tumors.

  Recruiting at 6 sites Phase 1/2 Tanabe Pharma America, Inc. · Los Angeles, California and 5 other locations · NCT06943521

• Combining chemotherapy with cetuximab and avelumab for advanced head and neck cancer

  This study is testing a new treatment plan that combines chemotherapy with two medications, cetuximab and avelumab, to see if it helps people with advanced head and neck cancer live longer without their disease getting worse.

  Recruiting at 3 sites Phase 2 Gruppo Oncologico del Nord-Ovest · Cagliari, CAGLIARI and 7 other locations · NCT06869473

• BVAC-E6E7 immunotherapy for HPV-positive head and neck cancer

  A one-time immunotherapy shot called BVAC-E6E7 is being tested to see if it helps adults with HPV-positive head and neck cancer that has come back or spread.

  Recruiting at 2 sites Phase 1/2 Cellid Co., Ltd. · Seoul and 1 other locations · NCT06797986

• [68Ga]Ga-FAPI-46 in Staging of Head and Neck Carcinomas

  This study is testing if a new imaging method can help doctors better stage head and neck cancers.

  Recruiting Phase 2 University of Lausanne Hospitals · Lausanne, Canton of Vaud · NCT06794372

• Adding fianlimab to cemiplimab versus cemiplimab alone for recurrent or metastatic head and neck squamous cell carcinoma

  This test sees if adding the experimental drug fianlimab to cemiplimab works better than cemiplimab alone for people with recurrent or metastatic PD-L1–positive head and neck squamous cell carcinoma.

  Recruiting at 38 sites Phase 2 Regeneron Pharmaceuticals · Los Angeles, California and 37 other locations · NCT06769698

• Comparing accelerated and standard radiotherapy for head and neck cancer after surgery

  This study is testing whether getting six radiation treatments a week instead of five can help patients with head and neck cancer who are starting treatment after surgery feel better and live longer.

  Recruiting at 3 sites Wake Forest University Health Sciences · Charlotte, North Carolina and 2 other locations · NCT06607406

• Combining INBRX-106 with Pembrolizumab for advanced head and neck cancer treatment

  This study is testing whether combining a new treatment called INBRX-106 with pembrolizumab can help people with advanced head and neck cancer that can't be treated with local therapies.

  Recruiting at 19 sites Phase 2/3 Inhibrx Biosciences, Inc · Duarte, California and 88 other locations · NCT06295731

• Assessing GTAEXS617 for advanced solid tumors

  This study is testing a new treatment called GTAEXS617 to see if it can help people with advanced solid tumors, like certain types of cancer, when other treatments haven't worked.

  Recruiting at 15 sites Phase 1/2 Exscientia AI Limited · Los Angeles, California and 14 other locations · NCT05985655

• Investigating AP203 for advanced solid tumors

  This study is testing a new treatment called AP203 to see if it can help adults with advanced solid tumors, like lung cancer and head and neck cancer, feel better and fight their disease.

  Recruiting Phase 1/2 AP Biosciences Inc. · Taipei · NCT05473156

• Zanzalintinib with immune checkpoint drugs for advanced solid tumors

  This trial will test whether zanzalintinib alone or combined with immune drugs (nivolumab, with or without ipilimumab or relatlimab) is safe and helps people with advanced or metastatic solid tumors such as renal cell, prostate, urothelial, and liver cancers.

  Recruiting at 101 sites Phase 1 Exelixis · Phoenix, Arizona and 121 other locations · NCT05176483

• Analyzing solid tumors for HLA loss and collecting T cells for CAR T-cell therapy

  This study is testing how often solid tumors lose a key protein that helps the immune system recognize them, while also collecting T cells from patients with high-risk cancers to prepare for future CAR T-cell therapy.

  Recruiting at 13 sites A2 Biotherapeutics Inc. · Gilbert, Arizona and 15 other locations · NCT04981119

• Treatment of solid tumors or lymphoma with VMD-928

  This study is testing a new oral medication called VMD-928 to see if it can help adults with advanced solid tumors or lymphoma that haven't improved with standard treatments.

  Recruiting at 13 sites Phase 1/2 VM Oncology, LLC · Santa Rosa, California and 12 other locations · NCT03556228

Related topics

Quick answers

How many Head and Neck Squamous Cell Carcinoma (HNSCC) clinical trials are recruiting right now?

23, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 21 countries. The most sites are in United States (13 trials), China (5 trials), France (4 trials), Italy (4 trials), Australia (3 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 7, Phase 1/2: 6, Phase 1: 6, Phase 2/3: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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