Condition

Head and Neck Cancers clinical trials and research

• 16Clinical trials
• 7NIH research projects
• 12Countries

Newest Head and Neck Cancers clinical trials

All recruiting trials (16)

• Cough Skill Training to Help Head and Neck Cancer Patients Recover Voluntary Cough

  Researchers will test whether a handheld cough device-based training can help people with head and neck cancer improve their voluntary cough function.

  Recruiting Boston University Charles River Campus · Boston, Massachusetts · NCT07756684

• HMB Supplements to See If they Help Inflammation and Recovery After Head and Neck Cancer Surgery

  This study tests whether taking HMB before surgery can reduce inflammation and improve recovery for adults with head and neck cancer undergoing tumor removal.

  Recruiting Federal University of Minas Gerais · Belo Horizonte, Minas Gerais · NCT07675421

• Dietary fiber and sarcopenia risk in head and neck cancer

  This observational study will track fiber intake and related biological markers in adults with head and neck cancer from diagnosis for six months to see if higher fiber intake relates to better muscle health and lower inflammation during treatment.

  Recruiting University of Oklahoma · Oklahoma City, Oklahoma · NCT07622914

• EPI-326 for EGFR-mutant non-small cell lung cancer and head and neck squamous cell carcinoma

  This phase 1 trial will try EPI-326, a new drug, in people with EGFR-mutant non‑small cell lung cancer or advanced head and neck squamous cell carcinoma to find safe doses, study how the body handles it, and look for early signs it shrinks tumors.

  Recruiting at 8 sites Phase 1 EpiBiologics · Los Angeles, California and 7 other locations · NCT07462377

• Group program to promote post-traumatic growth for adults with breast, colorectal, or head and neck cancer in Greece

  This project will try a manualized, group-based ACT program to help Greek adults who finished chemotherapy for breast, colorectal, or head and neck cancer increase post-traumatic growth and quality of life.

  Recruiting Centre for Research and Technology Hellas · Thessaloniki · NCT07108517

• Telemedicine follow-up for early laryngeal cancer patients

  This study tests if follow-up care through Telemedicine is just as good as in-person visits for people with early laryngeal cancer, especially for those who live far from treatment centers.

  Recruiting University Medical Center Groningen · Groningen, Provincie Groningen · NCT06940505

• IDOV-Immune for advanced solid tumors

  This trial will try a single IV infusion of an engineered oncolytic vaccinia virus called IDOV-Immune in adults with advanced solid tumors that no longer respond to standard treatments.

  Recruiting at 5 sites Phase 1 ViroMissile, Inc. · St Louis, Missouri and 4 other locations · NCT06910657

• Innovative OSA Screening in Head and Neck Cancer Patients with the Apneal App

  A smartphone app called Apneal is being tested to see if it can help diagnose sleep apnea in adults who are being evaluated for head and neck cancer.

  Recruiting University Hospital, Caen · Caen, France · NCT06896448

• Comparing face masks and no masks for head and neck radiation therapy

  This study tests whether using a face mask during radiation therapy for head and neck cancer makes patients feel more comfortable and less anxious compared to not using a mask.

  Recruiting University of Zurich · Zurich · NCT06870799

• New biomaterials approach to rebuild jaw and upper jaw after cancer surgery

  This study will see how adults who have part of their jaw or maxilla removed for head and neck cancer recover, what their quality of life is, and what medical and non-medical costs they have after reconstruction with a free bone flap.

  Recruiting University Hospital, Toulouse · Amiens and 8 other locations · NCT06771336

• Evaluating new imaging technology for cancer radiation therapy

  This study is testing a new imaging technology for cancer radiation therapy to see if it can provide better pictures than the standard method, helping patients get more effective treatment.

  Recruiting at 4 sites Varian, a Siemens Healthineers Company · Columbus, Ohio and 3 other locations · NCT06681233

• Using SCG142 TCR-T cells to treat HPV-related cancers

  This study is testing a new type of immune cell treatment called SCG142 TCR-T cells to see if it can help people with advanced cancers related to HPV.

  Recruiting Phase 1 The Affiliated Hospital of Qingdao University · Qingdao, Shandong · NCT06544720

• Digital health coaching for cancer survivors

  This study is testing whether a digital health coaching program can help cancer survivors feel better and improve their health after finishing treatment.

  Recruiting at 2 sites Pack Health · Gainesville, Florida and 6 other locations · NCT05349227

• Treatment of solid tumors or lymphoma with VMD-928

  This study is testing a new oral medication called VMD-928 to see if it can help adults with advanced solid tumors or lymphoma that haven't improved with standard treatments.

  Recruiting at 13 sites Phase 1/2 VM Oncology, LLC · Santa Rosa, California and 12 other locations · NCT03556228

• Comparing StrataXRT to standard care for preventing skin issues in head and neck cancer patients

  This study is testing if a new silicone gel called StrataXRT can help prevent skin problems in patients with head and neck cancer who are getting radiation treatment, compared to the usual cream they receive.

  Recruiting National University Hospital, Singapore · Singapore · NCT03394417

• Identifying blood and tissue markers for tumor hypoxia in head and neck and lung cancers

  This study is trying to find new blood and tissue markers that show low oxygen levels in tumors to help people with head and neck and lung cancers understand their condition better and improve treatment outcomes.

  Recruiting Stanford University · Stanford, California · NCT00568490

NIH-funded research (7)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Targeting mitochondria with a ceramide compound to treat head and neck cancer

  A new drug candidate called LCL768 aims to kill head and neck cancer cells by targeting their mitochondria and could also boost how well immunotherapy works.

  NIH research Lipo-Immuno Tech, LLC · Mount Pleasant, United States · NIH-11404364

• How some p53 gene changes help head and neck cancers spread and hide from the immune system

  Researchers are looking at whether blocking a protein called MCM5 can stop p53‑mutant head and neck cancers from becoming unstable, spreading, and weakening the immune system.

  NIH research University of Tx Md Anderson Can Ctr · Houston, United States · NIH-11300228

• Combining Cue-101 and engineered T cells to treat HPV-positive head and neck cancer

  Doctors are combining Cue-101 with specially engineered T cells to help people with HPV16-positive head and neck cancer by improving tumor targeting while using lower cell doses.

  NIH research Yale University · New Haven, United States · NIH-11294142

• Combining T cell therapy with a new treatment for HPV-related head and neck cancers

  This study is testing a new way to treat head and neck cancers linked to HPV by using specially modified immune cells that can find and fight the cancer, and it's for patients with HPV-positive cancers who want to explore a promising treatment option.

  NIH research Yale University · New Haven, United States · NIH-11038001

• How mutations in the TP53 gene affect cancer spread and immune response in head and neck cancers

  This study is looking at certain changes in a gene called TP53 that are often found in head and neck cancers to see how they affect how the cancer grows and avoids the immune system, with the hope of finding new treatments that could work better for patients like you.

  NIH research University of Tx Md Anderson Can Ctr · Houston, United States · NIH-11034107

• Using nanoscale frameworks to enhance cancer treatment and immunotherapy for head and neck cancers

  This study is exploring a new way to help people with head and neck cancers by using tiny materials that can boost radiation therapy and help the immune system fight the cancer better, aiming to improve treatment results and survival rates for patients.

  NIH research University of Chicago · Chicago, United States · NIH-10885971

• Finding ways to improve immune responses in head and neck cancers

  This study is looking at ways to improve immunotherapy for people with head and neck cancer, aiming to help more patients respond to treatment by figuring out why the immune system sometimes doesn't fight the cancer effectively.

  NIH research Yale University · New Haven, United States · NIH-10690599

Related topics

Quick answers

How many Head and Neck Cancers clinical trials are recruiting right now?

16, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 12 countries. The most sites are in United States (8 trials), France (2 trials), Greece (1 trial), Puerto Rico (1 trial), China (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 1: 3, Phase 1/2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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