[68Ga]Ga-FAPI-46 in Staging of Head and Neck Carcinomas
[68Ga]Ga-FAPI-46 PET/CT in Early Detection of Lymph Node Metastasis in Head and Neck Squamous Cell Carcinomas
PHASE2 · University of Lausanne Hospitals · NCT06794372
This study is testing if a new imaging method can help doctors better stage head and neck cancers.
Quick facts
| Phase | PHASE2 |
|---|---|
| Study type | Interventional |
| Enrollment | 20 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | University of Lausanne Hospitals (other) |
| Locations | 1 site (Lausanne, Canton of Vaud) |
| Trial ID | NCT06794372 on ClinicalTrials.gov |
What this trial studies
Processing failed - manual review needed
Who should consider this trial
Good fit: Unknown
Not a fit: Unknown
Why it matters
Potential benefit: Unknown
How similar studies have performed: Unknown
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age ≥18 years old * Karnofsky index ≥80% * Patients with operable head and neck cancer presenting histologically proven HNSCC (including Oral Cavity Cancer, Pharyngeal Cancer, Laryngeal Cancer) * Patients with at least one nodal metastasis * Patients scheduled for neck dissection * SOC imaging (MRI, ceCT and 18F-FDG-PET/CT) performed as pre-surgery exams * Written informed consent obtained Exclusion Criteria: * Known pregnancy or ongoing breast feeding * Claustrophobia * Severe renal insufficiency (GFR\<30 mL/min/1,73 m2) * Liver enzymes (ALAT, ASAT)\>5 times the standard upper limit * Bilirubin\>3 times the standard upper limit * Hemoglobin\<8 g/dL * Absolute neutrophil count\<1000/mm3 * Platelets\<75000/µL * insufficient knowledge of project language, inability to give consent or to follow trial-associated procedures * the patient makes use of his/her "right not to know" and refuses to be informed about incidental findings
Where this trial is running
Lausanne, Canton of Vaud
- Centre hospitalier universitaire vaudois — Lausanne, Canton of Vaud, Switzerland (RECRUITING)
Study contacts
- Principal investigator: Niklaus Schaefer, MD — Centre Hospitalier Universitaire Vaudois
- Study coordinator: John O Prior, MD, PhD
- Email: john.prior@chuv.ch
- Phone: +41 21 314 4348
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Head and Neck Squamous Cell Carcinoma HNSCC, Head and Neck Squamous Cell Carcinoma, Cancer-associated fibroblasts, PET/CT, Lymph nodes, Tumor microenvironment, Fibroblast activation protein
Last reviewed 2026-05-15 by the Find a Trial editorial team.
Information on this page is for educational purposes and is not medical advice.
Always consult qualified healthcare professionals about clinical trial participation.