Condition

Oral Cavity Squamous Cell Carcinoma clinical trials and research

• 11Clinical trials
• 6Countries

Newest Oral Cavity Squamous Cell Carcinoma clinical trials

All recruiting trials (11)

• Proton or Photon Radiotherapy Added to Pembrolizumab Before Surgery for Advanced or Recurrent Oral Cavity Cancer

  This phase 2 trial tests whether adding proton SFRT or SBRT to pembrolizumab before surgery helps patients with advanced or recurrent oral cavity cancer.

  Recruiting Phase 2 Mayo Clinic · Rochester, Minnesota · NCT07783581

• Selective neck dissection (levels I–IV) vs. modified neck dissection (levels I–V) in oral cavity cancer with a positive neck

  This trial tests whether a less extensive neck surgery can control cancer as well as the standard broader surgery in patients with one involved neck node from oral cavity cancer.

  Recruiting Kolhapur Cancer Centre - Cancer Centers of America · Kolhāpur, Maharashtra · NCT07717307

• Personalized neck radiation guided by sentinel lymph node biopsy for oral cavity cancer

  This phase II trial sees if using sentinel lymph node biopsy to guide which side(s) of the neck get radiation can safely reduce unnecessary radiation for people with oral cavity squamous cell carcinoma.

  Recruiting Phase 2 University of Michigan Rogel Cancer Center · Ann Arbor, Michigan · NCT07121595

• Personalized compartment-sparing postoperative radiation for head and neck cancer

  This trial tests whether targeted, compartment-sparing postoperative radiation can reduce side effects while keeping cancer control for people with surgically treated head and neck squamous cell carcinoma.

  Recruiting at 3 sites Phase 2 Insel Gruppe AG, University Hospital Bern · Basel and 2 other locations · NCT07058805

• Cemiplimab with or without CDX-1140 given before surgery for stage III-IV head and neck cancer

  This trial tests whether adding the immune stimulant CDX-1140 to cemiplimab before surgery helps shrink tumors in people with resectable stage III-IV head and neck squamous cell carcinoma.

  Recruiting at 12 sites Phase 2 National Cancer Institute (NCI) · Irvine, California and 11 other locations · NCT06980038

• Immune biomarker testing in cisplatin-ineligible head and neck squamous cell cancer patients treated with chemoradiation and docetaxel

  This project will test whether immune markers from tumor tissue, blood, saliva and stool can help predict outcomes and show increased tumor immune activity in people with oropharynx, hypopharynx, larynx or oral cavity squamous cell cancer who can't take cisplatin and are receiving chemoradiation with docetaxel.

  Recruiting University of Erlangen-Nürnberg Medical School · Erlangen, Bavaria · NCT06947668

• Remote hearing tests for patients with head and neck cancer receiving chemotherapy or radiation

  This study is testing if remote hearing tests can help patients with advanced head and neck cancer keep track of their hearing loss during chemotherapy or radiation, making it easier for those who live far away to participate.

  Recruiting Emory University · Atlanta, Georgia · NCT06662058

• Adding BMX-001, a drug that protects normal tissue from radiation damage, to standard chemoradiation for head and neck cancer

  This trial tests whether giving BMX-001 along with usual mouth-care reduces severe mouth sores in people getting cisplatin-based chemoradiation for HPV-related and other head and neck cancers.

  Recruiting at 146 sites Phase 2 NRG Oncology · Gilbert, Arizona and 152 other locations · NCT06532279

• Using nisin to treat oral cavity squamous cell carcinoma

  This study is testing if a natural food preservative called nisin can safely help people with oral cavity squamous cell carcinoma during their surgery and improve their health outcomes.

  Recruiting Phase 1/2 University of California, San Francisco · San Francisco, California · NCT06097468

• Combining sintilimab with reduced chemotherapy for oral cavity cancer treatment

  This study is testing if combining a new immune therapy called sintilimab with fewer chemotherapy sessions can help people with certain types of mouth cancer before they have surgery.

  Recruiting Phase 2 Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University · Guangzhou, Guangdong · NCT05098119

• Sentinel lymph node biopsy versus standard neck dissection for early-stage oral cavity cancer

  This trial tests whether removing only the sentinel lymph nodes instead of doing a full neck dissection helps people with early-stage oral cavity cancer have better neck and shoulder function while keeping cancer control the same.

  Recruiting at 88 sites Phase 2/3 NRG Oncology · Birmingham, Alabama and 106 other locations · NCT04333537

Related topics

Quick answers

How many Oral Cavity Squamous Cell Carcinoma clinical trials are recruiting right now?

11, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 6 countries. The most sites are in United States (7 trials), Canada (1 trial), Germany (1 trial), China (1 trial), India (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 6, Phase 2/3: 1, Phase 1/2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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