Condition

Hypopharyngeal Squamous Cell Carcinoma clinical trials and research

• 9Clinical trials
• 4Countries

Newest Hypopharyngeal Squamous Cell Carcinoma clinical trials

All recruiting trials (9)

• Neoadjuvant EGFR-ADC plus anti-PD-1 therapy for resectable locally advanced hypopharyngeal cancer

  This trial tests whether a targeted EGFR-ADC drug plus an anti-PD-1 antibody given before surgery can improve outcomes for adults with resectable locally advanced hypopharyngeal squamous cell carcinoma.

  Recruiting Phase 2 Tianjin Medical University Cancer Institute and Hospital · Tianjin, Tianjin Municipality · NCT07665190

• Window of Opportunity to Preserve Laryngeal Function

  This trial will try a short course of platinum chemotherapy plus paclitaxel and the immunotherapy toripalimab before surgery to see if adults with advanced laryngeal or hypopharyngeal squamous cell cancer can keep their voice box and still get good cancer control.

  Recruiting Phase 2 University of Pittsburgh · Pittsburgh, Pennsylvania · NCT07423078

• Personalized compartment-sparing postoperative radiation for head and neck cancer

  This trial tests whether targeted, compartment-sparing postoperative radiation can reduce side effects while keeping cancer control for people with surgically treated head and neck squamous cell carcinoma.

  Recruiting at 3 sites Phase 2 Insel Gruppe AG, University Hospital Bern · Basel and 2 other locations · NCT07058805

• Cemiplimab with or without CDX-1140 given before surgery for stage III-IV head and neck cancer

  This trial tests whether adding the immune stimulant CDX-1140 to cemiplimab before surgery helps shrink tumors in people with resectable stage III-IV head and neck squamous cell carcinoma.

  Recruiting at 12 sites Phase 2 National Cancer Institute (NCI) · Irvine, California and 11 other locations · NCT06980038

• Comparing two imaging techniques for assessing blood vessel effects in head and neck cancer patients receiving radiation therapy

  This study is testing if a new type of imaging can better spot blood vessel problems in head and neck cancer patients getting radiation therapy compared to the usual imaging method.

  Recruiting Early Phase 1 Emory University · Atlanta, Georgia · NCT06914999

• Remote hearing tests for patients with head and neck cancer receiving chemotherapy or radiation

  This study is testing if remote hearing tests can help patients with advanced head and neck cancer keep track of their hearing loss during chemotherapy or radiation, making it easier for those who live far away to participate.

  Recruiting Emory University · Atlanta, Georgia · NCT06662058

• Adding BMX-001, a drug that protects normal tissue from radiation damage, to standard chemoradiation for head and neck cancer

  This trial tests whether giving BMX-001 along with usual mouth-care reduces severe mouth sores in people getting cisplatin-based chemoradiation for HPV-related and other head and neck cancers.

  Recruiting at 146 sites Phase 2 NRG Oncology · Gilbert, Arizona and 152 other locations · NCT06532279

• Treatment for advanced laryngeal and hypopharyngeal cancer using chemotherapy and immunotherapy

  This study is testing if adding an immune therapy to chemotherapy can help people with advanced throat cancer keep their voice box while improving their chances of survival.

  Recruiting at 5 sites Phase 2 University of Leipzig · Mannheim, Baden-Würtemberg and 8 other locations · NCT06137378

• Comparing radiation therapy alone or with cisplatin for advanced head and neck cancer after surgery

  This study is testing whether adding the chemotherapy drug cisplatin to radiation therapy helps people with advanced head and neck cancer feel better after surgery compared to just radiation alone.

  Recruiting at 463 sites Phase 2 Eastern Cooperative Oncology Group · Birmingham, Alabama and 678 other locations · NCT02734537

Related topics

Quick answers

How many Hypopharyngeal Squamous Cell Carcinoma clinical trials are recruiting right now?

9, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 4 countries. The most sites are in United States (6 trials), Germany (1 trial), China (1 trial), Switzerland (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 7, Early Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

Describe your situation →