Combining PD-1 therapy with chemotherapy for advanced head and neck cancer

Efficacy and Safety of PD-1 Inhibitor Combined With Chemotherapy in Locally Advanced (III-IVB) Poorly Differentiated Head and Neck Squamous Cell Carcinoma: a Multi Cohort, Prospective Phase II Study

This study is testing if combining a new cancer treatment with chemotherapy can help people with advanced head and neck cancer feel better and have better outcomes.

Quick facts

• Phase: PHASE2
• Study type: Interventional
• Enrollment: 100 (estimated)
• Ages: 18 Years and up
• Sex: All
• Sponsor: Beijing Tongren Hospital (other)
• Drugs / interventions: chemotherapy
• Locations: 1 site (Beijing, Beijing Municipality)
• Trial ID: NCT06100497 on ClinicalTrials.gov

What this trial studies

This clinical trial evaluates the efficacy and safety of combining PD-1 therapy with platinum-based chemotherapy and albumin-bound paclitaxel in patients with poorly differentiated locally advanced head and neck squamous cell carcinoma. Participants will be divided into two groups, with one group receiving the combination treatment for 2 to 3 cycles, followed by surgery if they show a positive response. Blood and tumor tissue samples will be collected for genomic analysis to better understand treatment effects. The study aims to improve outcomes for patients with advanced disease who may not have many treatment options.

Who should consider this trial

Good fit: Ideal candidates are adults aged 18 and older with locally advanced poorly differentiated head and neck tumors who can safely receive the proposed treatment.

Not a fit: Patients with nasopharyngeal carcinoma or those with non-resectable tumors may not benefit from this study.

Why it matters

Potential benefit: If successful, this approach could significantly improve treatment outcomes for patients with advanced head and neck cancer.

How similar studies have performed: Other studies have shown promising results with similar combinations of immunotherapy and chemotherapy in various cancers, suggesting potential for success in this approach.

Eligibility criteria

Inclusion Criteria:

* Patients with locally advanced (III-IVB) poorly differentiated head and neck tumors (hypopharyngeal cancer, laryngeal cancer, oropharyngeal cancer, nasal cavity and sinus cancer, excluding nasopharyngeal cancer) with a confirmed diagnosis by histology and/or cytology;
* Patients who can receive systemic treatment or PD-1/L1 monotherapy before treatment;
* Patients in arm2 must be evaluated as having resectable tumors before treatment;
* The investigator believes that the patient can safely receive PD-1 combined with platinum-based and albumin-bound paclitaxel treatment;
* Age ≥ 18 years;
* ECOG (Eastern Cooperative Oncology Group) 0-1；
* Measurable disease defined by RECIST v1.1;
* Adequate bone marrow reserve and organ function: absolute neutrophil count (ANC) ≥ 1,000/μL, platelets ≥ 75,000/μL, hemoglobin ≥ 8g/dL, no transfusion or erythropoietin (EPO) dependence (within 7 days of assessment);
* Renal function: serum creatinine ≤ 1.5X upper limit of normal (ULN) OR measured or calculated creatinine clearance ≥ 60mL/min, creatinine level \> 1.5X institutional ULN. (GFR can also be used instead of creatinine or CrCl). Creatinine clearance should be calculated according to institutional standards;
* Liver function: For subjects with total bilirubin levels \>1.5 ULN, serum total bilirubin ≤1.5X ULN or direct bilirubin ≤ULN; For patients with liver metastasis, aspartate aminotransferase (AST/SGOT) and alanine aminotransferase (ALT/SGPT) ≤2.5X ULN or ≤5X ULN; Albumin \> 2.5 mg/dL;
* Coagulation function: International normalized ratio (INR) or prothrombin time (PT) ≤1.5X ULN, if subjects require anticoagulant therapy, PT or PTT (partial thromboplastin time) should be within the allowable range of anticoagulant use;
* Women should agree to use contraception during the study and for 6 months after the end of the study (such as intrauterine devices (IUDs), contraceptive pills, or condoms); Within 7 days before study enrollment, serum or urine pregnancy test should be negative, and patients must be non-lactating; Men should agree to use contraception during the study and for 6 months after the end of the study.

Exclusion Criteria:

* Patients who have previously received PD-1/L1 combined chemotherapy drugs;
* Patients with a history of other malignant tumors (including unknown primary) within the past 5 years. Note: Excluding stage 1 or 2 skin basal/squamous cell carcinoma or in situ carcinoma receiving potentially curative treatment;
* Patients who cannot tolerate postoperative radiotherapy;
* Patients known to be allergic to the study drug or its active ingredients or excipients;
* Patients with any unstable systemic diseases, including but not limited to: severe infection, uncontrolled diabetes, unstable angina, cerebrovascular accident or transient ischemic attack, myocardial infarction, congestive heart failure, severe -Patients with underlying immune deficiencies, chronic infections, including HIV, hepatitis, tuberculosis (TB), or autoimmune diseases;
* Patients with potential hematologic issues, including bleeding diathesis, known prior gastrointestinal bleeding requiring intervention within the past 6 months, active pulmonary embolism or deep vein thrombosis (DVT) unstable on anticoagulation regimen;
* History or evidence of active non-infectious pneumonia;
* Known active central nervous system (CNS) metastases and/or carcinomatous meningitis or leptomeningeal disease. Subjects with prior treated brain metastases may participate as long as they are stable (no evidence of imaging progression for at least four weeks prior to the first trial treatment and any neurological symptoms have returned to baseline), no new or enlarging brain metastases, and no use of steroids for at least 7 days prior to trial treatment. This exception does not include carcinomatous meningitis, which will be excluded regardless of clinical stability;
* Within 7 days before the first day of the first cycle, at the same time (or receiving) treatment with drugs that may affect drug metabolism;
* Pregnant or breastfeeding, or expecting to become pregnant or give birth during the expected trial period;
* Any uncontrolled concurrent disease, including but not limited to persistent or active infection, symptomatic congestive heart failure, unstable angina, arrhythmia;
* Screening EKG\> 475 ms prolonged corrected QT (QTc) interval;
* Ejection fraction \<40% by 2D echocardiogram (ECHO) during screening;
* Any serious medical or mental illness/symptoms, including substance use disorders, may interfere with or limit compliance with study requirements/treatments in the investigator's judgment;
* Having active autoimmune diseases requiring systemic treatment in the past 2 years (even with disease-modifying agents, corticosteroids, or immunosuppressive drugs). Alternative therapies (e.g., thyroid hormone, insulin, or physiological corticosteroid replacement therapy for adrenal or pituitary insufficiency) are not considered a form of systemic treatment.

Where this trial is running

Beijing, Beijing Municipality

• Beijing Tongren Hospital Affiliated to Capital Medical University — Beijing, Beijing Municipality, China (RECRUITING)

Study contacts

• Study coordinator: Xiaohong Chen, Doctor

Conditions: Head and Neck Squamous Cell Carcinoma