Condition

Gender Dysphoria clinical trials and research

• 12Clinical trials
• 1NIH research projects
• 5Countries

Newest Gender Dysphoria clinical trials

All recruiting trials (12)

• Brain health changes after gender-affirming hormone therapy in transgender adults

  This study tests how starting gender-affirming hormone therapy may affect brain blood flow, structure, connectivity, and cognitive function in transgender adults.

  Recruiting University of Wisconsin, Madison · Madison, Wisconsin · NCT07624747

• Topical estrogen cream to improve recovery for transgender men after hysterectomy

  This study tests if using a special estrogen cream after surgery can help transgender men recover better and feel more comfortable after a hysterectomy.

  Recruiting Phase 3 Women and Infants Hospital of Rhode Island · Providence, Rhode Island · NCT06969326

• Evaluating voice outcomes after gender-affirming voice surgeries

  This study is testing how different gender-affirming voice surgeries affect voice quality and patient satisfaction over time.

  Recruiting at 2 sites University Ghent · Ghent, East-Flanders and 1 other locations · NCT06439290

• Evaluating hormonal treatment for adolescents with gender dysphoria

  This study tests if giving cross-sex hormones to teens with gender dysphoria who have started their social transition helps them feel better and function well compared to those who don’t receive the hormones.

  Recruiting at 3 sites Phase 3 Assistance Publique - Hôpitaux de Paris · Paris and 3 other locations · NCT06351501

• Effects of gender-affirming hormone therapy on heart and metabolic health

  This study is trying to see how gender-affirming hormone therapy affects heart health, metabolism, and mental well-being in transgender people over several years.

  Recruiting Medical University of Vienna · Vienna, State of Vienna · NCT06291675

• Effects of hormone treatment on heart and liver health in transgender individuals

  This study tests how hormone treatment affects heart and liver health in transgender individuals by looking at changes before and after six months of therapy.

  Recruiting Medical University of Vienna · Vienna, State of Vienna · NCT06245681

• Hormonal treatment effects on transgender men

  This study tests if giving testosterone to transgender men for six weeks can help improve their feelings about their gender and boost their mental health compared to a placebo.

  Recruiting Karolinska University Hospital · Stockholm · NCT05649605

• Observational analysis of silicone gel-filled testicular implants

  This study is trying to see how well silicone gel-filled testicular implants work and how satisfied patients are after getting them, for people who need these implants due to various medical conditions.

  Recruiting University Hospital, Ghent · Ghent, East-Flanders · NCT05097820

• Assessing genital sensitivity and sexual function after gender-affirming surgery

  This study is trying to see how gender-affirming surgery affects genital sensitivity and sexual function in transgender individuals.

  Recruiting University Hospital, Ghent · Ghent, East-Flanders · NCT04993469

• Comparing pain management techniques for transgender patients undergoing gender-affirming surgeries

  This study is testing different ways to manage pain for transgender patients having gender-affirming surgeries to see which method works best for them.

  Recruiting Phase 3 Cedars-Sinai Medical Center · Los Angeles, California · NCT04979338

• Effects of Estradiol on Cardiometabolic Health in Transgender Youth

  This study tests how estradiol affects insulin sensitivity and blood vessel health in transgender girls aged 13-16 compared to girls who are not transgender.

  Recruiting University of Colorado, Denver · Aurora, Colorado · NCT04596592

• Evaluating outcomes of a new penile implant for transgender men after surgery

  This study is testing a new penile implant designed for transgender men to see if it can help improve erectile function after surgery.

  Recruiting University Hospital, Ghent · Ghent, Oost-Vlaanderen · NCT04064671

NIH-funded research (1)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• A new questionnaire for social gender dysphoria and stress

  This project will create a new questionnaire to capture the social distress people experience about their gender, especially for transgender and nonbinary individuals.

  NIH research Washington University · Saint Louis, United States · NIH-11005621

Related topics

Quick answers

How many Gender Dysphoria clinical trials are recruiting right now?

12, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 5 countries. The most sites are in Belgium (4 trials), United States (4 trials), Austria (2 trials), France (1 trial), Sweden (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 3: 3. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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