Effects of gender-affirming hormone therapy on heart and metabolic health

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study investigates the long-term effects of gender-affirming hormone therapy (GAHT) on cardiovascular health, insulin sensitivity, body composition, and psychological well-being in transgender individuals. Participants will be monitored over a period of 2, 5, and 10 years to assess changes in myocardial mass, cardiac function, and fat content in the heart, liver, and pancreas. The study aims to fill the gap in existing research regarding the mid- to long-term impacts of GAHT, which has been largely overlooked in previous studies.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* participation in our pilot study

  * ongoing gender affirming hormone therapy during the last 2 years
  * willingness and competence to sign the informed consent form.

Exclusion Criteria:

* age \< 18 years

  * non-MRI conditional implants, grafts, and/or devices
  * non-MRI conditional tattoos
  * claustrophobia
  * current substance abuse
  * pregnancy
  * failure to comply with the study protocol and/or not following the instructions of the study team.

Where it's running

• Chiari Stoffwechselambulanz, Medical University of Vienna
  Vienna, State of Vienna, Austria Recruiting

Study contacts

• Principal investigator: Alexandra Kautzky-Willer, Prof, MD — Medical University of Vienna
• Study coordinator: Carola Deischinger, MD PHD
• Email: carola.deischinger@meduniwien.ac.at
• Phone: +43140400

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.