Assessing genital sensitivity and sexual function after gender-affirming surgery

Patient Reported Outcome on Genital Sensitivity and Sexual Function After Genital Gender Affirming Surgery

Not applicable Interventional University Hospital, Ghent · NCT04993469

This study is trying to see how gender-affirming surgery affects genital sensitivity and sexual function in transgender individuals.

Quick facts

PhaseNot applicable
Study typeInterventional
Enrollment200 (estimated)
Ages18 Years to 110 Years
SexAll
SponsorUniversity Hospital, Ghent Academic / other
Locations1 site (Ghent, East-Flanders)
Trial IDNCT04993469 on ClinicalTrials.gov

What this trial studies

This study evaluates the impact of genital gender-affirming surgery on genital sensitivity and sexual functioning in individuals with gender dysphoria. It involves transgender males and females who wish to undergo surgeries such as phalloplasty, metoidioplasty, vaginoplasty, or vulvoplasty. Participants will undergo Semmes-Weinstein monofilament testing and complete questionnaires to assess their outcomes post-surgery. The goal is to better understand the relationship between surgical techniques and sexual function outcomes.

Who should consider this trial

Good fit: Ideal candidates include transgender individuals aged 18 and older with diagnosed gender dysphoria who are seeking genital gender-affirming surgery.

Not a fit: Patients who are cisgender or those who are unfit for surgery will not benefit from this study.

Why it matters

Potential benefit: If successful, this study could provide valuable insights into improving sexual function and satisfaction for transgender individuals post-surgery.

How similar studies have performed: While there have been studies on urological outcomes, this specific focus on genital sensitivity and sexual function post-surgery is relatively novel.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Voluntarily signed written informed consent according to the rules of Good Clinical Practice (Declaration of Helsinki) and national regulations
* Patient age ≥ 18 years
* Transgender male, female of gender non-conforming patient with diagnosed gender dysphoria and the specific wish to undergo genital gender affirming surgery
* Fit for operation, based on the surgeon's expert opinion
* Patient is able and willing to attend the follow-up consultations

Exclusion Criteria:

* Absence of signed written informed consent and thus a patient unwilling to participate.
* Patient age \< 18 years
* Cisgender patients
* Patients unfit for operation
* Patient declares that it will be impossible for him to attend the follow-up consultations

Where this trial is running

Ghent, East-Flanders

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions Gender DysphoriaPhalloplastyMetoidioplastyVaginoplastyVulvoplasty
Last reviewed 2026-06-09 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.