Topical estrogen cream to improve recovery for transgender men after hysterectomy
Official title: Topical Estrogen: Brief Intervention to Improve Postoperative Experience for Transgender Men Undergoing Hysterectomy
Run by Women and Infants Hospital of Rhode Island · NCT06969326 · Data updated 2026-11-12
This study tests if using a special estrogen cream after surgery can help transgender men recover better and feel more comfortable after a hysterectomy.
Quick facts
| Phase | Phase 3 |
|---|---|
| Study type | Interventional |
| Ages | 18 Years and up |
| Sex | Women only |
| Enrollment | 48 (estimated) |
| Sponsor | Women and Infants Hospital of Rhode Island Academic / other |
| Locations | 1 site (Providence, Rhode Island) |
| Status | Recruiting |
| Started | May 1, 2025 |
| Main results expected | September 1, 2026 |
| Study ends | December 1, 2026 |
| Registry record updated | May 13, 2025 |
| Trial ID | NCT06969326 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are transgender men aged 18 or older who have been on testosterone for at least six months and are planning to undergo a gender-affirming hysterectomy.
✕Probably not a fit
Patients who are under 18, have not been on testosterone for the required duration, or have known allergies to topical estrogen may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study investigates the effects of applying a single dose of topical estrogen cream at the end of a hysterectomy to enhance the postoperative experience for transgender men. The aim is to reduce postoperative bleeding and alleviate symptoms of dysphoria, which can be exacerbated by vaginal bleeding following surgery. By comparing outcomes between those receiving the estrogen treatment and those who do not, the study seeks to determine if this intervention should be integrated into standard postoperative care for this population. The findings could provide valuable insights into improving recovery experiences for transgender men undergoing gender-affirming surgeries.
Why it matters
Potential benefit: If successful, this intervention could significantly improve the postoperative experience and reduce dysphoria for transgender men undergoing hysterectomy.
How similar studies have gone: While the use of topical estrogen in this specific context is novel, similar approaches in managing postoperative care have shown promise in other studies.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Gender diverse/transgender men 2. Age 18 or older 3. Have been on testosterone for at least 6 months with plan to undergo gender-affirming hysterectomy and are willing to be randomized to the use of topical estrogen postoperatively. 4. Have stable physical and mental health 5. No contraindications to estrogen therapy 6. Must be proficient in English or Spanish 7. Must have access to a device to receive text messages for study follow up 8. Must agree to allow their medical data to be used for research purposes Exclusion Criteria: 1. Under age 18 2. Have not been on testosterone for at least 6 months prior to planned hysterectomy 3. Known allergy to topical estrogen
Where it's running
-
Women & Infants Hospital
Providence, Rhode Island, United States Recruiting
Study contacts
- Study coordinator: Beth Cronin, MD
- Email: bcronin@wihri.org
- Phone: 401-274-1122
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Predictors of Success and Failure of v-NOTES Hysterectomy for Large Uteri
This study looks at which factors predict whether a v-NOTES hysterectomy for large uteri will be completed without needing to switch to another surgical approach.
-
Hybrid robotic surgery for gynecologic procedures using ROB platform
This study tests whether the ROB robotic platform and its endoscopic instruments can be safely used to perform laparoscopic hysterectomy with or without removal of tubes and/or ovaries in adult women.
-
Biofeedback-Assisted Pelvic Floor Training After Hysterectomy
This study tests whether biofeedback-guided pelvic floor exercises after hysterectomy can improve pelvic floor strength, reduce urinary leakage, lessen genital prolapse, and boost quality of life.
-
Brain health changes after gender-affirming hormone therapy in transgender adults
This study tests how starting gender-affirming hormone therapy may affect brain blood flow, structure, connectivity, and cognitive function in transgender adults.
-
Effectiveness of M-TAPA nerve block for pain relief after laparoscopic hysterectomy
This study tests whether the M-TAPA nerve block before surgery can reduce opioid use and pain after laparoscopic hysterectomy compared with standard pain care.
-
Reading a personal narrative book to help emotional regulation before hysterectomy in young women
This trial tests whether reading a personal narrative book in addition to usual care can help young women preparing for hysterectomy feel calmer and less anxious or depressed.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.