Topical estrogen cream to improve recovery for transgender men after hysterectomy
Topical Estrogen: Brief Intervention to Improve Postoperative Experience for Transgender Men Undergoing Hysterectomy
This study tests if using a special estrogen cream after surgery can help transgender men recover better and feel more comfortable after a hysterectomy.
Quick facts
| Phase | Phase 3 |
|---|---|
| Study type | Interventional |
| Enrollment | 48 (estimated) |
| Ages | 18 Years and up |
| Sex | Female |
| Sponsor | Women and Infants Hospital of Rhode Island Academic / other |
| Locations | 1 site (Providence, Rhode Island) |
| Trial ID | NCT06969326 on ClinicalTrials.gov |
What this trial studies
This study investigates the effects of applying a single dose of topical estrogen cream at the end of a hysterectomy to enhance the postoperative experience for transgender men. The aim is to reduce postoperative bleeding and alleviate symptoms of dysphoria, which can be exacerbated by vaginal bleeding following surgery. By comparing outcomes between those receiving the estrogen treatment and those who do not, the study seeks to determine if this intervention should be integrated into standard postoperative care for this population. The findings could provide valuable insights into improving recovery experiences for transgender men undergoing gender-affirming surgeries.
Who should consider this trial
Good fit: Ideal candidates are transgender men aged 18 or older who have been on testosterone for at least six months and are planning to undergo a gender-affirming hysterectomy.
Not a fit: Patients who are under 18, have not been on testosterone for the required duration, or have known allergies to topical estrogen may not benefit from this study.
Why it matters
Potential benefit: If successful, this intervention could significantly improve the postoperative experience and reduce dysphoria for transgender men undergoing hysterectomy.
How similar studies have performed: While the use of topical estrogen in this specific context is novel, similar approaches in managing postoperative care have shown promise in other studies.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Gender diverse/transgender men 2. Age 18 or older 3. Have been on testosterone for at least 6 months with plan to undergo gender-affirming hysterectomy and are willing to be randomized to the use of topical estrogen postoperatively. 4. Have stable physical and mental health 5. No contraindications to estrogen therapy 6. Must be proficient in English or Spanish 7. Must have access to a device to receive text messages for study follow up 8. Must agree to allow their medical data to be used for research purposes Exclusion Criteria: 1. Under age 18 2. Have not been on testosterone for at least 6 months prior to planned hysterectomy 3. Known allergy to topical estrogen
Where this trial is running
Providence, Rhode Island
- Women & Infants Hospital — Providence, Rhode Island, United States (Recruiting)
Study contacts
- Study coordinator: Beth Cronin, MD
- Email: bcronin@wihri.org
- Phone: 401-274-1122
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.