Brain health changes after gender-affirming hormone therapy in transgender adults

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study examines brain changes in transgender adults before and about 4–6 months after starting GAHT. Researchers will use MRI to measure cerebral blood flow, brain structure, and functional connectivity, along with cognitive tests. The study compares baseline results to a follow-up visit after GAHT initiation to identify potential sex-differentiated effects on neurocognitive function and brain networks. Participants include individuals assigned male or female at birth who are planning GAHT and meet specific health criteria. Optional exercise testing may be added to explore additional brain-health interactions.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* intention to undergo GAHT

Exclusion Criteria:

* BMI greater than 40 kg/m2
* Age greater than 45 yrs
* Blood pressure greater than 140/90 (stage II hypertension)
* A current diagnosis of type II diabetes
* History of traumatic brain injury/concussion, stroke, or seizures
* Are post-menopausal
* Previously taken hormone therapy medications
* Self-reported pregnancy (no pregnancy test)

Where it's running

• UW School of Medicine and Public Health
  Madison, Wisconsin, United States Recruiting

Study contacts

• Principal investigator: William Schrage, PhD — University of Wisconsin, Madison
• Study coordinator: Shawn Bolin, MS
• Email: sbolin@wisc.edu
• Phone: 608-263-6308

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.