Effects of hormone treatment on heart and liver health in transgender individuals

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to investigate the impact of cross-sex hormone therapy on cardiovascular function and fat content in the liver and heart among transgender individuals. Participants will undergo two MRI scans, one before starting hormone treatment and another after six months of therapy, to assess changes in their cardiovascular health. Additionally, an oral glucose tolerance test will be conducted at both time points to evaluate metabolic changes. The study seeks to clarify the gender-specific cardiovascular changes associated with high-dose hormone therapy in male-to-female and female-to-male transgender individuals.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* DSM-IV diagnosis of Gender Identity Disorder
* age over 18 years

Exclusion Criteria:

* age under 18 years severe neurological or internal diseases

  * steroid hormone treatment within 2 months prior to inclusion (including birth control pill, phytohormones)
  * treatment with psychotropic agents such as SSRIs
  * any implant or stainless-steel graft
  * abnormal values in routine laboratory screening or general physical examination
  * current substance abuse (determined using drug screening at the screening visit)
  * pregnancy (determined at screening visit and first MRI scan)
  * failure to comply with the study protocol or to follow the instructions of the investigating

Where it's running

• Chiari Stoffwechselambulanz, Medical University of Vienna
  Vienna, State of Vienna, Austria Recruiting

Study contacts

• Study coordinator: Carola Deischinger, MD PhD
• Email: carola.deischinger@meduniwien.ac.at
• Phone: +43140400

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Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.