Condition

Fever clinical trials and research

• 12Clinical trials
• 80NIH research projects
• 1New in 30 days
• 7Countries

Newest Fever clinical trials

All recruiting trials (12)

• See if Buzzy and virtual reality help kids get IV lines faster

  This study tests whether a vein-imaging device plus virtual reality or the same device plus a pain-reducing tool can make peripheral IV placement easier for children aged 7–12 with fever.

  Recruiting Bandırma Onyedi Eylül University · Bursa · NCT07882602

• Triage performance and physiological predictors of serious illness in febrile children in the pediatric emergency department

  This study tests whether the initial color-coded triage category and vital signs at triage can predict serious outcomes in febrile children who come to pediatric emergency departments in Turkey.

  Recruiting at 10 sites TC Erciyes University · Kayseri, Talas and 9 other locations · NCT07739004

• Turning anonymous symptom descriptions into structured biological signals with OpenGenome

  This project tries to turn adults' anonymous free-text symptom descriptions submitted to OpenGenome into structured, literature-grounded biological signals using PubMed and ClinicalTrials.gov sources and a constrained reasoning model.

  Recruiting OpenGenome · Friedrichshain, State of Berlin · NCT07578610

• How long to take sulfamethoxazole after a kidney transplant

  This study will test whether different lengths of sulfamethoxazole (TMP‑SMX) taken after a kidney transplant better prevent Pneumocystis jirovecii pneumonia in adult transplant recipients.

  Recruiting Anhui Provincial Hospital · Hefei, Anhui · NCT07231770

• Safety of giving an RSV preventive antibody with routine childhood vaccines

  This trial will test whether giving an RSV preventive antibody at the same visit as routine childhood vaccines is as safe for infants 6 to <30 weeks old as giving the antibody at a separate visit.

  Recruiting at 5 sites Phase 4 Duke University · Oakland, California and 5 other locations · NCT07158814

• Providing weight-based prescriptions for fever medicine to reduce emergency department return visits for young children.

  This will test if giving caregivers weight-based prescriptions for acetaminophen and ibuprofen to children aged 6 to 35 months when they leave the ED reduces unscheduled return visits within one week.

  Recruiting University of Texas at Austin · Austin, Texas · NCT07074912

• Point-of-care fingertip CRP testing to guide care for febrile children

  We will test a small fingertip (capillary) C‑reactive protein (CRP) test in primary care to help doctors decide care for children with fever who need a CRP measurement.

  Recruiting at 37 sites Centre Hospitalier Universitaire de Nīmes · Agde and 36 other locations · NCT06910631

• Monitoring temperature remotely in cancer patients at risk for fever

  This study tests if using a remote thermometer to monitor cancer patients' temperatures can help prevent fevers and reduce hospital stays after chemotherapy.

  Recruiting AION Biosystems · Schenectady, New York · NCT06752512

• Investigating how local anesthetic temperature affects maternal fever during childbirth

  This study tests whether using warmer or cooler local anesthetics during labor can help reduce the chances of mothers getting a fever while receiving epidural pain relief.

  Recruiting The First Affiliated Hospital of Soochow University · Suzhou, Jiangsu and 1 other locations · NCT06682416

• Identifying pathogens in febrile patients using gene expression

  This study is trying to find out if looking at gene responses in feverish patients can help doctors quickly tell if they have enteric fever or another infection, especially in places with limited resources.

  Recruiting University of Sheffield · Vellore · NCT04878549

• Using antibiotics to prevent infections in patients with gastric varices undergoing treatment

  This study is testing if giving antibiotics to patients with liver disease and gastric varices during treatment can help prevent infections and reduce the chances of bleeding again.

  Recruiting Phase 4 Taipei Veterans General Hospital, Taiwan · Taipei · NCT04140578

• Exploring genetics and characteristics of familial Mediterranean fever and related disorders

  This study is trying to understand the genetics and symptoms of diseases that cause fever, like familial Mediterranean fever, by looking at patients, their families, and healthy volunteers.

  Recruiting National Institutes of Health Clinical Center (CC) · Washington D.C., District of Columbia and 4 other locations · NCT00001373

NIH-funded research (newest 40 of 80)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Broad antiviral drugs that target coronaviruses and other viruses

  A research program aims to identify small molecules that can block multiple viruses, focusing first on coronaviruses, to help create drugs that can treat future outbreaks.

  NIH research Hackensack University Medical Center · Hackensack, United States · NIH-11617025

• Finding broadly protective antibodies against Crimean-Congo Hemorrhagic Fever

  Researchers will study blood from people who survived CCHF to find human antibodies that protect against multiple virus variants, with early tests in animal models to check their breadth.

  NIH research University of Maryland Baltimore · Baltimore, United States · NIH-11556149

• Antivirals for hemorrhagic fever viruses like LASV, SFTSV, and EBOV

  A multi-institutional effort to find and validate antiviral compounds that block key viral proteins from LASV, SFTSV, and EBOV to help people at risk from serious hemorrhagic fevers.

  NIH research Scripps Research Institute, the · La Jolla, United States · NIH-11542060

• A New Model for Valley Fever: Studying Coccidioides Infection with Volatile Clues in Wax Moths

  Researchers are testing a new, cheaper model using wax moths to study Valley Fever caused by Coccidioides, with the goal of understanding how the infection behaves and how it could be diagnosed or treated.

  NIH research Arizona State University-Tempe Campus · Scottsdale, United States · NIH-11439036

• Halogen-modified nucleoside analogs to fight yellow fever virus

  Aims to develop new oral medicines that could prevent or treat yellow fever by using specially modified building blocks that stop the virus from growing.

  NIH research Emory University · Atlanta, United States · NIH-11430119

• Understanding Guanarito virus and building countermeasures for Venezuelan hemorrhagic fever

  This project studies how Guanarito virus causes disease and aims to develop vaccines or treatments to protect people in areas where Venezuelan hemorrhagic fever occurs.

  NIH research University of Texas Med Br Galveston · Galveston, United States · NIH-11428214

• Fever-related heat and disturbed blood flow weaken the artery lining via a cellular stress pathway

  This study will explore how fever-range heat and uneven blood flow together harm the inner lining of arteries, especially in areas prone to atherosclerosis, by triggering a specific cellular stress pathway.

  NIH research Nova Southeastern University · Fort Lauderdale-Davie, UNITED STATES · NIH-11425069

• Humanized antibody to prevent and treat Q fever

  A new antibody-based approach aims to prevent and treat Q fever in people by using a humanized monoclonal antibody.

  NIH research Zenvax, LLC · Helotes, UNITED STATES · NIH-11420515

• Broadly protective antibodies for Crimean-Congo Hemorrhagic Fever

  Researchers will study antibodies from people who survived Crimean-Congo Hemorrhagic Fever to find ones that can neutralize many viral strains and test them in a mouse model for potential future therapies.

  NIH research University of Maryland Baltimore · Baltimore, United States · NIH-11403811

• PANDAA universal test for Crimean-Congo hemorrhagic fever (CCHFV)

  A new rapid diagnostic test aims to detect all lineages of Crimean-Congo hemorrhagic fever virus to help people with fever symptoms get timely answers and care.

  NIH research Aldatu Biosciences, INC. · Watertown, UNITED STATES · NIH-11393717

• Rocky Mountain Spotted Fever vaccine development for people and dogs

  A vaccine is being developed to prevent Rocky Mountain spotted fever, a tick-borne disease that can be severe in people and dogs.

  NIH research University of Missouri-Columbia · Columbia, United States · NIH-11387476

• How soft ticks (Ornithodoros turicata) pass relapsing fever bacteria to their offspring

  This project checks whether soft ticks called Ornithodoros turicata keep and pass relapsing fever bacteria across generations, which matters for people living or working where these ticks live.

  NIH research Baylor College of Medicine · Houston, United States · NIH-11386993

• Innate immune sensing of Rift Valley fever virus in human cells

  This grant studies how human immune cells recognize Rift Valley fever virus and what that means for disease such as fever, hepatitis, or brain inflammation.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11386411

• Neuropathogenesis of Rift Valley Fever Virus: How RVFV reaches the brain after a bite

  This grant studies how Rift Valley Fever virus can move from a mosquito bite to the brain, aiming to prevent brain disease from this infection.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11384728

• Morning light to improve sleep and reduce inflammation in multiple myeloma patients after stem cell transplant

  A multi-site study will test whether exposure to circadian-friendly morning light helps multiple myeloma patients recover after autologous stem cell transplantation by improving sleep and reducing inflammation.

  NIH research Icahn School of Medicine at Mount Sinai · New York, United States · NIH-11384508

• Point-of-care test for Lassa and other arenavirus infections

  A Duke research team is developing a fast, easy-to-use test to rapidly detect Lassa and related arenavirus infections, so people in affected regions can get quick care.

  NIH research Duke University · Durham, United States · NIH-11381848

• Novel Lassa fever vaccine platform with built‑in safety features

  A new live-attenuated Lassa fever vaccine platform is being developed to safely protect people in West Africa by creating a durable immune response with multiple safety mechanisms.

  NIH research Scripps Research Institute, the · La Jolla, United States · NIH-11373069

• Unraveling why the yellow fever vaccine works and why rare reactions happen

  This project studies how the yellow fever 17D vaccine triggers the immune system and why a small number of people have serious adverse reactions.

  NIH research Rockefeller University · New York, United States · NIH-11373046

• Understanding how Crimean-Congo hemorrhagic fever virus glycoproteins assemble and cause disease

  Researchers are studying how the CCHFV virus builds its outer proteins and how these proteins help the virus enter cells and cause illness in order to develop future protections.

  NIH research Albert Einstein College of Medicine · Bronx, United States · NIH-11372981

• Improving early detection of yellow fever outbreaks in Ghana

  Aiming to quickly spot yellow fever outbreaks in Ghana by creating risk maps, measuring how fast diagnoses happen, and testing smarter ways to use diagnostic resources.

  NIH research University of California Los Angeles · Los Angeles, United States · NIH-11364164

• How teen binge drinking might change brain-driven fever and immune responses

  This work looks at whether heavy alcohol use during the teen years changes how the brain controls fever and immune responses to infections and vaccinations.

  NIH research State University of Ny,binghamton · Binghamton, United States · NIH-11334327

• Sensitive point-of-care test for tick-borne spotted fever group rickettsioses

  A fast, easy-to-use test kit is being developed to detect early signs of tick-borne spotted fever group infections so patients can get treated sooner.

  NIH research Inbios International, INC. · Seattle, UNITED STATES · NIH-11313004

• How typhoid and paratyphoid bacteria cause and persist in infection

  Using mice with human immune cells, the team is finding how typhoid and paratyphoid bacteria hide inside human immune cells to help people with enteric fever.

  NIH research University of Washington · Seattle, United States · NIH-11284029

• Vaping vitamin E acetate may create a new toxic chemical that causes fever and lung inflammation

  This work looks at whether heating vitamin E acetate in vaping devices forms a previously missed toxic compound that can cause fever and lung inflammation in people who vape.

  NIH research Indiana University Indianapolis · Indianapolis, United States · NIH-11257340

• Developing a treatment for Lassa fever virus

  This study is working on developing a new treatment for Lassa fever, aiming to find safe and effective options that could help people who are affected by this serious illness.

  NIH research Sri International · Menlo Park, United States · NIH-11250785

• How Rift Valley fever virus packages its genetic material

  Researchers are working to understand how Rift Valley fever virus packs its RNA to help prevent illness in people and animals.

  NIH research University of Texas Med Br Galveston · Galveston, United States · NIH-11237090

• Antibody that blocks New World arenaviruses from entering human cells

  This project is developing an antibody that stops New World arenaviruses from entering human cells to protect people at risk of viral hemorrhagic fever.

  NIH research University of California Los Angeles · Los Angeles, United States · NIH-11224086

• Identifying tick species that spread Crimean-Congo Hemorrhagic Fever virus

  This study is all about figuring out which types of ticks can spread the Crimean-Congo Hemorrhagic Fever virus, so we can find better ways to identify them and help keep everyone safe from tick-borne illnesses.

  NIH research Georgia Southern University · Statesboro, United States · NIH-11220492

• New vaccine approaches for Crimean-Congo hemorrhagic fever

  Testing two inactivated virus-based vaccine designs intended to protect people at risk of Crimean-Congo hemorrhagic fever.

  NIH research Thomas Jefferson University · Philadelphia, United States · NIH-11174272

• Developing a Safe Lassa Fever Vaccine

  This project is creating a new, safer vaccine to protect people from Lassa fever, a serious illness found in West Africa.

  NIH research Scripps Research Institute, the · La Jolla, United States · NIH-11173710

• How Rift Valley fever virus reaches the brain

  Researchers are finding out how Rift Valley fever virus moves from a mosquito bite into the brain so future treatments and preventions can be developed.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11172450

• Understanding how the Crimean-Congo hemorrhagic fever virus works

  This project aims to understand how the Crimean-Congo hemorrhagic fever virus causes severe illness, helping us find ways to fight it.

  NIH research Albert Einstein College of Medicine · Bronx, United States · NIH-11170632

• How the protein IL-38 controls fever and inflammation

  This work is seeing if IL-38 can calm inflammation and fever in people with autoimmune and other inflammatory conditions.

  NIH research University of Colorado Denver · Aurora, UNITED STATES · NIH-11168734

• Universal molecular test for Crimean‑Congo hemorrhagic fever

  A rapid molecular test that can detect all genetic variants of the virus that causes Crimean‑Congo hemorrhagic fever in people with suspected infection.

  NIH research Aldatu Biosciences, INC. · Watertown, UNITED STATES · NIH-11145788

• Finding broadly protective antibodies for Crimean‑Congo hemorrhagic fever

  Researchers are collecting blood from people who recovered from Crimean‑Congo hemorrhagic fever to find antibodies that could protect others from the virus.

  NIH research University of Maryland Baltimore · Baltimore, United States · NIH-11143287

• Rapid point-of-care tests for Lassa and related hemorrhagic fever viruses

  This project will create quick, easy tests to detect Lassa and similar arenaviruses so people in affected areas can get a diagnosis faster.

  NIH research Duke University · Durham, United States · NIH-11140446

• How the body detects Rift Valley fever virus

  Researchers are looking at how cells in the body detect and fight Rift Valley fever virus in adults at risk of infection, to understand why some people get severe fever, liver damage, or brain inflammation.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11140361

• Vaping a specific vitamin E compound can create a harmful substance that causes lung issues and fever.

  This study is looking at how vaping a certain vitamin E compound might cause lung problems, like inflammation and fever, in both people and animals, to help us understand the risks of using vaping products with this ingredient.

  NIH research Indiana University Indianapolis · Indianapolis, United States · NIH-11139759

• Understanding the Yellow Fever Vaccine and Rare Side Effects

  This work helps us understand how the yellow fever vaccine protects most people and why a small number experience serious reactions.

  NIH research Rockefeller University · New York, United States · NIH-11138557

• Morning light to reset the body clock for multiple myeloma patients having autologous stem cell transplant

  This project uses bright, circadian-friendly morning light in hospital rooms for people with multiple myeloma receiving autologous stem cell transplants to help them sleep better, lower inflammation, and reduce fevers and symptom burden.

  NIH research Icahn School of Medicine at Mount Sinai · New York, United States · NIH-11137688

Related topics

Quick answers

How many Fever clinical trials are recruiting right now?

12, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 7 countries. The most sites are in United States (4 trials), Turkey (Türkiye) (2 trials), China (2 trials), India (1 trial), France (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 4: 2. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

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