How long to take sulfamethoxazole after a kidney transplant

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The trial enrolls adult kidney transplant recipients who will receive time-driven sulfamethoxazole (TMP‑SMX) prophylaxis according to predefined dosing schedules to compare infection outcomes. Participants will be followed clinically with testing for PJP using sputum GMS stain, direct immunofluorescence or PCR on induced sputum or BALF, and metagenomic next‑generation sequencing when indicated. The design targets the observed pattern of PJP incidence, which shows a peak around 9 months and a second peak between 10 and 15 months after transplantation. The goal is to clarify an optimal prophylaxis duration where current guideline recommendations and clinical practice vary.

Why it matters

Who can join: the full rules

Diagnostic Criteria for PJP (meeting one of the following criteria is sufficient):

1. Detection of Pneumocystis jirovecii via sputum Gomori methenamine silver (GMS) stain.
2. According to guidelines/consensus: Positive direct immunofluorescence assay and/or positive polymerase chain reaction (PCR) assay on induced sputum or bronchoalveolar lavage fluid (BALF) specimens.
3. Detection of Pneumocystis jirovecii strains in sputum, blood, or bronchoalveolar lavage fluid (BALF) by metagenomic next-generation sequencing (mNGS).

Inclusion Criteria:

* Subjects must meet all the following conditions to be enrolled: (1) Age: 18-70 years old; (2) Post-renal transplantation; (3) Voluntarily participate in this clinical study, be able to cooperate with researchers to conduct the study, and sign the informed consent form.

Exclusion Criteria:

* Criteria: Subjects with any of the following conditions shall be excluded from the trial: (1) HIV-positive; (2) History of TMP-SMX allergy; (3) Glucose-6-phosphate dehydrogenase (G6PD) deficiency; (4) Megaloblastic anemia; (5) Multiorgan transplantation; (6) Complicated with tumor; (7) Complicated with connective tissue disease; (8) Pregnant patients.

Where it's running

• No. 17, Lujiang Road, Luyang District, Hefei City, Anhui Province, China
  Hefei, Anhui, China Recruiting

Study contacts

• Study coordinator: Xuqin Jiang
• Email: xqjiang@ustc.edu.cn
• Phone: 13675605989

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.