Investigating how local anesthetic temperature affects maternal fever during childbirth
Official title: The Impact of Local Anesthetic Solution Temperature on Epidural-related Maternal Fever
Run by The First Affiliated Hospital of Soochow University · NCT06682416 · Data updated 2026-11-12
This study tests whether using warmer or cooler local anesthetics during labor can help reduce the chances of mothers getting a fever while receiving epidural pain relief.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | Women only |
| Enrollment | 424 (estimated) |
| Sponsor | The First Affiliated Hospital of Soochow University Academic / other |
| Locations | 2 sites (Suzhou, Jiangsu and 1 other locations) |
| Status | Recruiting |
| Started | November 30, 2024 |
| Main results expected | October 1, 2027 |
| Study ends | October 1, 2027 |
| Registry record updated | September 11, 2025 |
| Trial ID | NCT06682416 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are pregnant women aged 18 or older, at least 37 weeks of gestation, who are requesting epidural analgesia for vaginal delivery.
✕Probably not a fit
Patients who may not benefit from this study include those with contraindications to epidural analgesia, pre-existing fever, or multiple pregnancies.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study examines the effect of local anesthetic solution temperature on the incidence of maternal fever related to epidural analgesia during labor. It is a prospective, randomized controlled trial involving 424 participants from two hospitals. Participants will receive either 37°C or 23°C anesthetic solutions, and the study will measure fever rates, pain scores, and various maternal and neonatal outcomes. The research aims to clarify the relationship between anesthetic temperature and intrapartum fever, potentially improving pain management and reducing complications during childbirth.
Why it matters
Potential benefit: If successful, this study could lead to improved management of maternal fever during labor, enhancing safety and outcomes for both mothers and newborns.
How similar studies have gone: While the specific approach of manipulating local anesthetic temperature is novel, previous studies have indicated a significant incidence of maternal fever related to epidural analgesia, suggesting that this area of research is both relevant and necessary.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Requesting epidural analgesia; 2. Aged 18 or older; 3. At least 37 weeks of gestation; 4. Those delivering vaginally. Exclusion Criteria: 1. Contraindications to epidural analgesia; 2. Pre-existing fever (≥38°C) before labor; 3. Use of NSAIDs or other types of antipyretics before labor; 4. Multiple pregnancy (carrying more than one fetus); 5. Fetal demise (stillbirth); 6. Severe preeclampsia; 7. Women who refuse to participate.
Where it's running
-
Ethical Committee of the First Affiliated Hospital of Soochow University
Suzhou, Jiangsu, China Recruiting -
Suzhou Municipal Hospital
Suzhou, Jiangsu, China Not yet recruiting
Study contacts
- Principal investigator: Fuhai Ji — The First Affiliated Hospital of Soochow University
- Study coordinator: Dapeng Chen
- Email: hisoka52@outlook.com
- Phone: +8618550044050
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.