Understanding how the Crimean-Congo hemorrhagic fever virus works
Official title: Reverse-engineering a viral Swiss army knife: Crimean-Congo hemorrhagic fever virus glycoprotein functions in assembly, entry, and in vivo pathogenesis
Funded at Albert Einstein College of Medicine · NIH-11170632 · Data updated 2026-11-12
This project aims to understand how the Crimean-Congo hemorrhagic fever virus causes severe illness, helping us find ways to fight it.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Albert Einstein College of Medicine NIH-funded |
| Lab location | 1 site (Bronx, United States) |
| Project start | August 15, 2024 |
| Project end | July 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $585,670 |
| NIH project number | 5R01AI185073-02 |
| Project ID | NIH-11170632 on NIH RePORTER |
Who could benefit from this research
✓Could help
This foundational research does not directly involve patient participation but aims to benefit individuals at risk of or infected with Crimean-Congo hemorrhagic fever in the future.
✕Less likely to help
Patients currently suffering from Crimean-Congo hemorrhagic fever would not directly benefit from this early-stage laboratory research.
What this research studies
Crimean-Congo hemorrhagic fever virus (CCHFV) is a serious tick-borne illness with no approved treatments. Our team is working to understand the virus's special proteins that help it assemble, enter cells, and cause disease. By studying these proteins, we hope to uncover how the virus infects people and makes them sick. This knowledge is crucial for developing new medicines and vaccines to protect people from this dangerous infection.
Why it matters
Potential benefit: If successful, this work could lead to the development of new treatments or vaccines for Crimean-Congo hemorrhagic fever, a severe and often deadly disease.
How similar studies have gone: While specific approaches to CCHFV glycoproteins are novel, understanding viral proteins has been successful in developing treatments for other viruses.
Where this research is happening
-
Albert Einstein College of Medicine
Bronx, United States Active
Researchers
- Principal investigator: Chandran, Kartik — Albert Einstein College of Medicine
- Study coordinator: Chandran, Kartik
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.