Halogen-modified nucleoside analogs to fight yellow fever virus
Official title: Combating yellow fever virus infections with halogen-modified nucleoside analogs
Funded at Emory University · NIH-11430119 · Data updated 2026-11-12
Aims to develop new oral medicines that could prevent or treat yellow fever by using specially modified building blocks that stop the virus from growing.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project start | August 18, 2026 |
| Project end | July 31, 2031 |
| Funding year | 2026 |
| Award (this year) | $1,057,832 |
| NIH project number | 1R01AI201320-01 |
| Project ID | NIH-11430119 on NIH RePORTER |
Who could benefit from this research
✓Could help
Individuals at risk for yellow fever or patients with yellow fever could benefit from future treatments or preventive options once approved.
✕Less likely to help
People without yellow fever or those in whom the compounds prove unsafe or ineffective may not benefit.
What this research studies
This project focuses on creating and testing new nucleotide-like compounds that target yellow fever virus. Researchers will optimize lead molecules for better potency and safety, study how they interact with the virus and viral enzymes, and evaluate how the best candidates behave in animals to understand dosing and possible side effects. The goal is to identify oral drugs that could protect against, or treat, yellow fever in people if approved. The work builds on prior findings that halogen-modified nucleosides may inhibit YFV in cells and mice.
Why it matters
Potential benefit: If successful, it could lead to an effective oral antiviral for yellow fever, reducing illness and death.
How similar studies have gone: Previous studies showed in vitro and mouse protection by halogen-modified nucleoside analogs against YFV, suggesting potential with further optimization.
Where this research is happening
-
Emory University
Atlanta, United States Active
Researchers
- Principal investigator: Schinazi, Raymond Felix — Emory University
- Study coordinator: Schinazi, Raymond Felix
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.